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Literature summary extracted from

  • Otto, H.; Reche, P.A.; Bazan, F.; Dittmar, K.; Haag, F.; Koch-Nolte, F.
    In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs) (2005), BMC Genomics, 6, 139.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30 gene PARP, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Mus musculus
2.4.2.30 gene PARP1, chromosomal location 1q41-q42, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP11, chromosomal location 12p13.3, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP14, chromosomal location 3q21.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP16, chromosomal location 15q22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP2, chromosomal location 14q11.2-q12, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP3, chromosomal location 3p21.1-22.2, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP4, chromosomal location 13q11, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene PARP6, chromosomal location 15q22.23, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens
2.4.2.30 gene TNKS1, chromosomal location 8p23.1, DNA and amino acid sequence determination, exon compositions, phylogenetic analysis, identification of two subgroups of the family of PARP-like poly(ADP-ribosyl)transferases, depending on the active site residues, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Mus musculus
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Homo sapiens
-
 nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Homo sapiens O95271 TNKS1
-
2.4.2.30 Homo sapiens P09874 PARP-1
-
2.4.2.30 Homo sapiens Q2NL67 PARP-6
-
2.4.2.30 Homo sapiens Q460N5 PARP-14
-
2.4.2.30 Homo sapiens Q8N5Y8 PARP-16
-
2.4.2.30 Homo sapiens Q9NR21 PARP-11
-
2.4.2.30 Homo sapiens Q9UGN5 PARP-2
-
2.4.2.30 Homo sapiens Q9UKK3 PARP-4
-
2.4.2.30 Homo sapiens Q9Y6F1 PARP-3
-
2.4.2.30 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains Mus musculus
a
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ the pART catalytic domain is found associated in Lego-like fashion with a variety of domains, including nucleic acid-binding, protein-protein interaction, and ubiquitylation domains Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Mus musculus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor
-
 Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 B aggressive lymphoma protein 2
-
 Homo sapiens
2.4.2.30 More the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs Mus musculus
2.4.2.30 More the enzyme belongs to the family of PARP-like poly(ADP-ribosyl)transferases, pARTs Homo sapiens
2.4.2.30 PARP
-
 Mus musculus
2.4.2.30 PARP
-
 Homo sapiens
2.4.2.30 TANK1
-
 Homo sapiens
2.4.2.30 tankyrase I
-
 Homo sapiens
2.4.2.30 TNKS-1
-
 Homo sapiens
2.4.2.30 TRF1-interacting ankyrin-related ADP-ribose polymerase
-
 Homo sapiens