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Literature summary extracted from

  • Zea, C.J.; Pohl, N.L.
    Unusual sugar nucleotide recognition elements of mesophilic vs. thermophilic glycogen synthases (2005), Biopolymers, 79, 106-113.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.11 adenine
-
 Pyrococcus furiosus
2.4.1.11 ADP
-
 Pyrococcus furiosus
2.4.1.11 AMP
-
 Pyrococcus furiosus
2.4.1.11 D-glucose
-
 Pyrococcus furiosus
2.4.1.11 D-glucose-1-phosphate
-
 Pyrococcus furiosus
2.4.1.11 UDP
-
 Pyrococcus furiosus
2.4.1.11 UDP-galactose
-
 Pyrococcus furiosus
2.4.1.11 UMP
-
 Pyrococcus furiosus
2.4.1.11 uridine
-
 Pyrococcus furiosus
2.4.1.242 adenosine
-
 Pyrococcus furiosus
2.4.1.242 ADP
-
 Pyrococcus furiosus
2.4.1.242 AMP
-
 Pyrococcus furiosus
2.4.1.242 D-glucose
-
 Pyrococcus furiosus
2.4.1.242 D-glucose 1-phosphate
-
 Pyrococcus furiosus
2.4.1.242 UDP
-
 Pyrococcus furiosus
2.4.1.242 UDP-galactose competitive Pyrococcus furiosus
2.4.1.242 UMP
-
 Pyrococcus furiosus
2.4.1.242 uridine
-
 Pyrococcus furiosus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.11 3.9
-
 GDP-glucose 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 4
-
 dTDP-glucose 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 4.1
-
 UDP-glucose 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 4.1
-
 ADP-glucose 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.242 3.9
-
 GDP-glucose
-
 Pyrococcus furiosus
2.4.1.242 4
-
 dTDP-glucose
-
 Pyrococcus furiosus
2.4.1.242 4.1
-
 UDP-glucose
-
 Pyrococcus furiosus
2.4.1.242 4.1
-
 ADP-glucose
-
 Pyrococcus furiosus

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.11 Pyrococcus furiosus
-
-
-
2.4.1.242 Pyrococcus furiosus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.11 ADP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus ADP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.11 dTDP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus dTDP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.11 GDP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus GDP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.11 UDP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus UDP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.242 ADP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus ADP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.242 dTDP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus dTDP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.242 GDP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus GDP + (1,4-alpha-D-glucosyl)n+1
-
 ?
2.4.1.242 additional information the enzyme gains most of its substrate affinity through electrostatic interactions between the enzyme and the alpha-phosphate. No activity with UDP-galactose, no phosphorylase activity Pyrococcus furiosus ?
-
 ?
2.4.1.242 UDP-glucose + (1,4-alpha-D-glucosyl)n
-
 Pyrococcus furiosus UDP + (1,4-alpha-D-glucosyl)n+1
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.11 3.7
-
 AMP 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 5.4
-
 ADP 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 5.4
-
 UDP 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 6.5
-
 UMP 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 17
-
 UDP-galactose 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 90
-
 uridine 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 120
-
 D-glucose-1-phosphate 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 290
-
 D-glucose 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.11 580
-
 adenine 80°C, pH 5.0 Pyrococcus furiosus
2.4.1.242 3.7
-
 AMP
-
 Pyrococcus furiosus
2.4.1.242 5.4
-
 ADP
-
 Pyrococcus furiosus
2.4.1.242 5.4
-
 UDP
-
 Pyrococcus furiosus
2.4.1.242 6.5
-
 UMP
-
 Pyrococcus furiosus
2.4.1.242 17
-
 UDP-galactose
-
 Pyrococcus furiosus
2.4.1.242 90
-
 uridine
-
 Pyrococcus furiosus
2.4.1.242 120
-
 D-glucose 1-phosphate
-
 Pyrococcus furiosus
2.4.1.242 290
-
 D-glucose
-
 Pyrococcus furiosus
2.4.1.242 580
-
 adenosine
-
 Pyrococcus furiosus