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Literature summary extracted from
- Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities (2005), Biophys. J., 89, 876-884.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.3.1.9 | medicine | tuberculosis, TB, target of anti-tubercular agents | Mycobacterium tuberculosis |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.3.1.9 | I16T | isoniazid resistant clinical mutant, in silico constructed | Mycobacterium tuberculosis |
| 1.3.1.9 | I21V | isoniazid resistant clinical mutant, in silico constructed | Mycobacterium tuberculosis |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.3.1.9 | 0.056 | - |
NADH | wild type enoyl-ACP reductase | Mycobacterium tuberculosis |  |
| 1.3.1.9 | 0.104 | - |
NADH | I21V mutant enoyl-ACP reductase | Mycobacterium tuberculosis | |
| 1.3.1.9 | 0.149 | - |
NADH | I16T mutantwild type enoyl-ACP reductase | Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.9 | acyl-[acyl-carrier protein] + NAD+ | Mycobacterium tuberculosis | - |
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.3.1.9 | Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.3.1.9 | acyl-[acyl-carrier protein] + NAD+ | - |
Mycobacterium tuberculosis | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.3.1.9 | enoyl reductase | - |
Mycobacterium tuberculosis |
| 1.3.1.9 | enoyl-ACP reductase | - |
Mycobacterium tuberculosis |
| 1.3.1.9 | enoyl-[acyl-carrier-protein] reductase | - |
Mycobacterium tuberculosis |
| 1.3.1.9 | InhA | - |
Mycobacterium tuberculosis |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.3.1.9 | NADH | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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