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Literature summary extracted from

  • Rong, F.; Chow, S.; Yan, S.; Larson, G.; Hong, Z.; Wu, J.
    Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 1663-1666.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.48 (2E)-3-(4-[[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclopentyl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[1-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[1-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2E)-3-[4-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2Z)-3-[4-([[1-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 (2Z)-3-[4-([[1-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
-
 Hepacivirus C
2.7.7.48 2,3-bis(4-fluorophenyl)quinoxaline-6-carboxylic acid
-
 Hepacivirus C
2.7.7.48 2,3-bis(4-methylphenyl)quinoxaline-6-carboxylic acid
-
 Hepacivirus C
2.7.7.48 2,3-di-2-furylquinoxaline-6-carboxylic acid
-
 Hepacivirus C
2.7.7.48 2,3-diphenylquinoxaline-6-carboxylic acid
-
 Hepacivirus C
2.7.7.48 5-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 5-(4-[[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)furan-2-carboxylic acid
-
 Hepacivirus C
2.7.7.48 5-(4-[[(3-cyclohexyl-2-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)furan-2-carboxylic acid
-
 Hepacivirus C
2.7.7.48 5-hydroxy-N-[[3-(3-methoxyphenyl)-2-(4-methoxyphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 6-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 ethyl (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoate
-
 Hepacivirus C
2.7.7.48 ethyl (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclopentyl]carbonyl]amino)phenyl]prop-2-enoate
-
 Hepacivirus C
2.7.7.48 ethyl (2E)-3-[4-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoate
-
 Hepacivirus C
2.7.7.48 methyl 5-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl 6-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-difuran-2-ylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-dipyridin-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-(2-methoxy-2-oxoethoxy)-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-[[(2E)-4-methoxy-4-oxobut-2-en-1-yl]oxy]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-(2-methoxy-2-oxoethoxy)-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-[[(2E)-4-methoxy-4-oxobut-2-en-1-yl]oxy]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 methyl N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
-
 Hepacivirus C
2.7.7.48 N-[(2,3-difuran-2-ylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-difuran-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-dipyridin-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(3-cyclohexyl-2-phenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[(3-cyclohexyl-2-phenylquinoxalin-6-yl)carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-(carboxymethoxy)-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-[[(2E)-3-carboxyprop-2-en-1-yl]oxy]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-(carboxymethoxy)-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-[[(2E)-3-carboxyprop-2-en-1-yl]oxy]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
-
 Hepacivirus C
2.7.7.48 N-[[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
-
 Hepacivirus C

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Hepacivirus C P26663
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Hepacivirus C diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 NS5B
-
 Hepacivirus C
2.7.7.48 NS5B RdRp
-
 Hepacivirus C
2.7.7.48 NS5B RNA-dependent RNA polymerase
-
 Hepacivirus C

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.48 0.0006
-
-
 Hepacivirus C N-[(3-cyclohexyl-2-phenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.00069
-
-
 Hepacivirus C (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0012
-
-
 Hepacivirus C (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclopentyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0013
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.0013
-
-
 Hepacivirus C (2E)-3-(4-[[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)prop-2-enoic acid
2.7.7.48 0.0013
-
-
 Hepacivirus C (2E)-3-[4-([[1-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0013
-
-
 Hepacivirus C (2Z)-3-[4-([[1-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0013
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophan
2.7.7.48 0.0016
-
-
 Hepacivirus C N-[[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
2.7.7.48 0.0016
-
-
 Hepacivirus C 5-(4-[[(3-cyclohexyl-2-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)furan-2-carboxylic acid
2.7.7.48 0.0017
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-(carboxymethoxy)-L-tryptophan
2.7.7.48 0.0017
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-(carboxymethoxy)-L-tryptophan
2.7.7.48 0.0018
-
-
 Hepacivirus C N-[(3-cyclohexyl-2-phenylquinoxalin-6-yl)carbonyl]-L-tryptophan
2.7.7.48 0.0018
-
-
 Hepacivirus C 5-(4-[[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]amino]phenyl)furan-2-carboxylic acid
2.7.7.48 0.0019
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
2.7.7.48 0.0022
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-[[(2E)-3-carboxyprop-2-en-1-yl]oxy]-L-tryptophan
2.7.7.48 0.0022
-
-
 Hepacivirus C N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-[[(2E)-3-carboxyprop-2-en-1-yl]oxy]-L-tryptophan
2.7.7.48 0.0032
-
-
 Hepacivirus C 5-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
2.7.7.48 0.0032
-
-
 Hepacivirus C 6-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
2.7.7.48 0.0034
-
-
 Hepacivirus C N-[[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
2.7.7.48 0.0037
-
-
 Hepacivirus C N-[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]-L-tryptophan
2.7.7.48 0.0041
-
-
 Hepacivirus C N-[[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.0041
-
-
 Hepacivirus C (2E)-3-[4-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0046
-
-
 Hepacivirus C N-[[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.0046
-
-
 Hepacivirus C (2E)-3-[4-([[3-cyclohexyl-2-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.005
-
-
 Hepacivirus C N-[(2-cyclohexyl-3-phenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.0051
-
-
 Hepacivirus C (2E)-3-[4-([[1-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0051
-
-
 Hepacivirus C (2Z)-3-[4-([[1-([[2-cyclohexyl-3-(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0055
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophanate
2.7.7.48 0.0055
-
-
 Hepacivirus C 2,3-bis(4-fluorophenyl)quinoxaline-6-carboxylic acid
2.7.7.48 0.0055
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophanate
2.7.7.48 0.0061
-
-
 Hepacivirus C N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.0061
-
-
 Hepacivirus C N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophan
2.7.7.48 0.0069
-
-
 Hepacivirus C (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.0086
-
-
 Hepacivirus C methyl 5-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
2.7.7.48 0.0086
-
-
 Hepacivirus C methyl 6-(2-amino-2-oxoethoxy)-N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
2.7.7.48 0.01
-
-
 Hepacivirus C N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.011
-
-
 Hepacivirus C N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophan
2.7.7.48 0.015
-
-
 Hepacivirus C N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-L-tryptophan
2.7.7.48 0.015
-
-
 Hepacivirus C 5-hydroxy-N-[[3-(3-methoxyphenyl)-2-(4-methoxyphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan
2.7.7.48 0.015
-
-
 Hepacivirus C N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophan
2.7.7.48 0.016
-
-
 Hepacivirus C N-[(2,3-difuran-2-ylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophan
2.7.7.48 0.016
-
-
 Hepacivirus C N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophan
2.7.7.48 0.017
-
-
 Hepacivirus C (2E)-3-[4-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoic acid
2.7.7.48 0.017
-
-
 Hepacivirus C 2,3-di-2-furylquinoxaline-6-carboxylic acid
2.7.7.48 0.026
-
-
 Hepacivirus C methyl N-[(2,3-difuran-2-ylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophanate
2.7.7.48 0.026
-
-
 Hepacivirus C methyl N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophanate
2.7.7.48 0.033
-
-
 Hepacivirus C N-[(2,3-difuran-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophan
2.7.7.48 0.033
-
-
 Hepacivirus C N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophan
2.7.7.48 0.037
-
-
 Hepacivirus C ethyl (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclobutyl]carbonyl]amino)phenyl]prop-2-enoate
2.7.7.48 0.04
-
-
 Hepacivirus C 2,3-bis(4-methylphenyl)quinoxaline-6-carboxylic acid
2.7.7.48 0.049
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-5-hydroxy-L-tryptophanate
2.7.7.48 0.049
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophanate
2.7.7.48 0.053
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-[[(2E)-4-methoxy-4-oxobut-2-en-1-yl]oxy]-L-tryptophanate
2.7.7.48 0.053
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-[[(2E)-4-methoxy-4-oxobut-2-en-1-yl]oxy]-L-tryptophanate
2.7.7.48 0.072
-
-
 Hepacivirus C methyl N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-5-hydroxy-L-tryptophanate
2.7.7.48 0.072
-
-
 Hepacivirus C methyl N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-6-hydroxy-L-tryptophanate
2.7.7.48 0.079
-
-
 Hepacivirus C 2,3-diphenylquinoxaline-6-carboxylic acid
2.7.7.48 0.1
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-5-(2-methoxy-2-oxoethoxy)-L-tryptophanate
2.7.7.48 0.1
-
-
 Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-6-(2-methoxy-2-oxoethoxy)-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C ethyl (2E)-3-[4-([[1-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)cyclopentyl]carbonyl]amino)phenyl]prop-2-enoate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C ethyl (2E)-3-[4-([[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]amino)phenyl]prop-2-enoate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[(2,3-diphenylquinoxalin-6-yl)carbonyl]-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[(2,3-dipyridin-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[(2,3-ditetrahydrofuran-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-6-hydroxy-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[[2,3-bis(4-fluorophenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C methyl N-[[2,3-bis(4-methylphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophanate
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C N-[(2,3-dipyridin-2-ylquinoxalin-6-yl)carbonyl]-L-tryptophan
2.7.7.48 0.1
-
 IC50 above 0.1 mM Hepacivirus C N-[[2,3-bis(3-methoxyphenyl)quinoxalin-6-yl]carbonyl]-L-tryptophan