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Literature summary extracted from

  • Cooper, C.L.; Stob, C.M.; Jones, M.A.; Lash, T.D.
    Metabolism of pentacarboxylate porphyrinogens by highly purified human coproporphyrinogen oxidase: further evidence for the existence of an abnormal pathway for heme biosynthesis (2005), Bioorg. Med. Chem., 13, 6244-6251.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.3.3.3 medicine abnormal route for heme biosynthesis in humans suffering from porphyria cutanea tarda or related syndromes such as hexachlorobenzene poisoning Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.3 expressed in Escherichia coli BL21(DE3) cells Homo sapiens
1.3.3.3 expression in Escherichia coli Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.3.3 0.00054
-
 Coproporphyrinogen-III total product Homo sapiens
1.3.3.3 0.00054
-
 Coproporphyrinogen III pH and temperature not specified in the publication Homo sapiens
1.3.3.3 0.00055
-
 Coproporphyrinogen-III divinyl as product Homo sapiens
1.3.3.3 0.00097
-
 Coproporphyrinogen-III monovinyl as product Homo sapiens
1.3.3.3 0.0013
-
 pentacarboxylate porphyrinogen 5dab monovinyl as product Homo sapiens
1.3.3.3 0.0013
-
 pentacarboxylate porphyrinogen 5dab total product Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.3 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.3.3.3 37000
-
 1 * 37000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2 Homo sapiens
-
 coproporphyrin III + H2O
-
 ?
1.3.3.3 protoporphyrinogen IX + O2 Homo sapiens
-
 protoporphyrin IX + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.3.3 by Ni2+ affinity chromatography Homo sapiens
1.3.3.3 Ni2+ affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2
-
 Homo sapiens coproporphyrin III + H2O
-
 ?
1.3.3.3 coproporphyrinogen-III + O2 + 2 H+
-
 Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 additional information pentacarboxylate porphyrinogens 5abc, 5abd, and 5acd are not metabolized Homo sapiens ?
-
 ?
1.3.3.3 pentacarboxylate porphyrinogen 5dab + O2 poorer substrate than coproporphyrinogen-III Homo sapiens dehydroisocoproporphyrinogen
-
 ?
1.3.3.3 protoporphyrinogen IX + O2
-
 Homo sapiens protoporphyrin IX + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.3.3.3 monomer 1 * 37000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 copro'gen oxidase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.3.3.3 0.0033
-
 Coproporphyrinogen-III monovinyl as product Homo sapiens
1.3.3.3 0.009
-
 pentacarboxylate porphyrinogen 5dab monovinyl as product Homo sapiens
1.3.3.3 0.009
-
 pentacarboxylate porphyrinogen 5dab total product Homo sapiens
1.3.3.3 0.0125
-
 Coproporphyrinogen-III divinyl as product Homo sapiens
1.3.3.3 0.01616
-
 Coproporphyrinogen-III total product Homo sapiens
1.3.3.3 0.017
-
 Coproporphyrinogen III pH and temperature not specified in the publication Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.3.3.3 3.5
-
 Coproporphyrinogen III pH and temperature not specified in the publication Homo sapiens