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Literature summary extracted from

  • Tosaki, T.; Sakamoto, H.; Kitahara, J.; Imai, H.; Nakagawa, Y.
    Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide (2007), Biol. Pharm. Bull., 30, 272-278.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.67 diethyl maleate enhanced 3-fold upon treatment with 5 mM H2O2 Homo sapiens
2.3.1.67 H2O2 increased in concentration-dependent manner, fast but transitory activation, concentrations of H2O2 ranging from 1 to 10 mM, maximal effect at 10 mM, maximum reached within 20 min Homo sapiens
2.3.1.67 additional information membrane-permeable oxidants more effective to provoke synthesis of platelet-activating factor (PAF), no effect on synthesis of platelet-activating factor (PAF) observed in cells treated with 10 mM 2,2'-azobis(2-amidinopropane) dihydrochloride or with 5 mM hydrophobic cumen hydroperoxide Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.67 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid i.e. Trolox, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells Homo sapiens
2.3.1.67 N-acetylcysteine reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells Homo sapiens
2.3.1.67 pyrrolidinecarbodithioic acid i.e. PDTC, reduces production of platelet-activating factor (PAF) in H2O2-treated HUVEC cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor Homo sapiens
-
 platelet-activating factor + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.67 Homo sapiens
-
-
-
2.3.1.67 Homo sapiens Q7L5N7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.67 HUVEC cell activity is enhanced in H2O2-treated cells Homo sapiens
-
2.3.1.67 HUVEC cell H2O2-stimulated Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.67 additional information
-
 exogenous addition of lyso-platelet-activating factor (PAF) without effect on acetyltransferase activity, block of enzyme activity by a tyrosine kinase inhibitor and a calmodulin antagonist in H2O2-stimulated cells suggests involvement of tyrosine kinase and calcium/calmodulin-dependent protein kinase in regulation of enzyme activity Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor
-
 Homo sapiens platelet-activating factor + CoA
-
 ?
2.3.1.67 acetyl-CoA + lyso-platelet-activating factor intracellular redox state involved in regulating synthesis of platelet-activating factor (PAF) Homo sapiens platelet-activating factor + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.67 acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase
-
 Homo sapiens
2.3.1.67 acetyl-CoA:lysoPAF acetyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.67 37
-
 activity assay at Homo sapiens