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Literature summary extracted from

  • Choubey, V.; Guha, M.; Maity, P.; Kumar, S.; Raghunandan, R.; Maulik, P.R.; Mitra, K.; Halder, U.C.; Bandyopadhyay, U.
    Molecular characterization and localization of Plasmodium falciparum choline kinase (2006), Biochim. Biophys. Acta, 1760, 1027-1038.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.32 expressed in Escherichia coli Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.32 ethanolamine poor inhibitor Plasmodium falciparum
2.7.1.32 phosphocholine 40% and 66% inhibition at 2.5 mM and 10 mM, respectively Plasmodium falciparum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.32 0.145
-
choline in 100 mM Tris/HCl, 6 mM MgCl2, 5 mM ATP, pH 8.8, at 37°C Plasmodium falciparum
2.7.1.32 2.5
-
ATP in 100 mM Tris/HCl, 6 mM MgCl2, 5 mM ATP, pH 8.8, at 37°C Plasmodium falciparum
2.7.1.32 5
-
ethanolamine in 100 mM Tris/HCl, 6 mM MgCl2, 5 mM ATP, pH 8.8, at 37°C Plasmodium falciparum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.32 cytosol
-
Plasmodium falciparum 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.32 52200
-
calculated from amino acid sequence Plasmodium falciparum
2.7.1.32 56000
-
SDS-PAGE, recombinant protein Plasmodium falciparum

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Plasmodium falciparum
-
clone NF54
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.32 Ni-NTA agarose resin column chromatography and 300SW gel filtration Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
Plasmodium falciparum ADP + O-phosphocholine
-
?
2.7.1.32 ATP + ethanolamine can not phosphorylate ethanolamine efficiently Plasmodium falciparum ADP + ethanolamine phosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 PfCK
-
Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.32 8.8
-
-
Plasmodium falciparum

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.32 ATP
-
Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.32 3.45
-
phosphocholine in 100 mM Tris/HCl, 6 mM MgCl2, 5 mM ATP, pH 8.8, at 37°C Plasmodium falciparum
2.7.1.32 5.5
-
ethanolamine in 100 mM Tris/HCl, 6 mM MgCl2, 5 mM ATP, pH 8.8, at 37°C Plasmodium falciparum