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Literature summary extracted from

  • Gostimskaya, I.S.; Cecchini, G.; Vinogradov, A.D.
    Topography and chemical reactivity of the active-inactive transition-sensitive SH-group in the mitochondrial NADH:ubiquinone oxidoreductase (Complex I) (2006), Biochim. Biophys. Acta, 1757, 1155-1161.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 additional information insensitive to 0.5 mM 5,5-dithiobis-(2-nitrobenzoate) and 10 mM oxidized glutathione at pH 8.0 Bos taurus
7.1.1.2 additional information insensitive to 0.5 mM 5,5-dithiobis-(2-nitrobenzoate) and 10 mM oxidized glutathione at pH 8.0 Rattus norvegicus
7.1.1.2 N-ethylmaleimide 0.5 mM, strong inhibition Bos taurus
7.1.1.2 N-ethylmaleimide 0.5 mM, strong inhibition Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Rattus norvegicus 5739
-
7.1.1.2 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-
7.1.1.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Rattus norvegicus
-
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone
-
 Rattus norvegicus NAD+ + ubiquinol
-
 ?
7.1.1.2 NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Rattus norvegicus
7.1.1.2 NADH:ubiquinone oxidoreductase
-
 Bos taurus
7.1.1.2 respiratory complex I
-
 Rattus norvegicus
7.1.1.2 respiratory complex I
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Rattus norvegicus
7.1.1.2 NADH
-
 Bos taurus