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Literature summary extracted from
- Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants (2006), Biochim. Biophys. Acta, 1757, 115-122.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | riboflavin | 0.001 mg/ml | Caenorhabditis elegans |  |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | A352V | mutation in the 51 kDa subunit, shows mildly decreased NADH-dependent respiration and lactic acidosis | Caenorhabditis elegans |
| 7.1.1.2 | A443F | mutation in the 51 kDa subunit, shows decreased NADH-dependent respiration and lactic acidosis | Caenorhabditis elegans |
| 7.1.1.2 | T434M | mutation in the 51 kDa subunit, shows decreased NADH-dependent respiration and lactic acidosis | Caenorhabditis elegans |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | rotenone | 0.002 mg/ml | Caenorhabditis elegans | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.2 | mitochondrion | - |
Caenorhabditis elegans | 5739 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.1.1.2 | 51000 | - |
nuo-I subunit of wild type enzyme, SDS-PAGE | Caenorhabditis elegans |
| 7.1.1.2 | 950000 | - |
whole wild type enzyme, SDS-PAGE | Caenorhabditis elegans |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | Caenorhabditis elegans | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | NADH + 2,3-dimethoxy-5-methyl-6-[(6-methyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone | - |
Caenorhabditis elegans | NAD+ + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | complex I | - |
Caenorhabditis elegans |
| 7.1.1.2 | NADH-ubiquinone oxidoreductase | - |
Caenorhabditis elegans |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | NADH | - |
Caenorhabditis elegans | |
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Release 2023.1 (January 2023)
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