Literature summary extracted from

Sugishima, M.; Higashimoto, Y.; Oishi, T.; Takahashi, H.; Sakamoto, H.; Noguchi, M.; Fukuyama, K.
X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase (2007), Biochemistry, 46, 1860-1867.

Application

EC Number	Application	Comment	Organism
1.14.14.18	medicine	potential therapeutic target in cancer	Rattus norvegicus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.18	2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane	1 mM, potent inhibitor	Rattus norvegicus
1.14.14.18	Cr-containing protoporphyrin IX	potent inhibitor	Rattus norvegicus

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
1.14.14.18	33000	-	SDS-PAGE	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.18	Rattus norvegicus	P06762	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
1.14.14.18	hydroxylapatite column chromatography and POROS-HQ column chromatography	Rattus norvegicus

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
1.14.14.18	4.712	-	HO-2	Rattus norvegicus
1.14.14.18	8.413	-	HO-1	Rattus norvegicus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.18	heme + electron donor + O2	-	Rattus norvegicus	biliverdin + Fe2+ + CO + oxidized eletron donor + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.18	HO-1	-	Rattus norvegicus

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Release 2023.1 (January 2023)