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Literature summary extracted from
- The productive conformation of prostaglandin G2 at the peroxidase site of prostaglandin endoperoxide H synthase: docking, molecular dynamics, and site-directed mutagenesis studies (2006), Biochemistry, 45, 811-820.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.99.1 | expressed in COS-1 cells | Homo sapiens |
| 1.14.99.1 | into the mammalian expression vector pcDNA3 | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | K211A | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211A/K215A | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211A/K215A/K222A | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211A/K222A | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211E | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211E/K215E | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211E/K215E/K222E | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K211E/K222E | complete abolition of activity | Homo sapiens |
| 1.14.99.1 | K215A | does not impair PGHS activity | Homo sapiens |
| 1.14.99.1 | K215A/K222A | significant reduction of 27% of the activity | Homo sapiens |
| 1.14.99.1 | K215E | does not impair PGHS activity | Homo sapiens |
| 1.14.99.1 | K215E/K222E | significant reduction of 58% of the activity | Homo sapiens |
| 1.14.99.1 | K222A | no significant reduction of activity | Homo sapiens |
| 1.14.99.1 | K222E | no significant reduction of activity | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | aspirin | - |
Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.1 | endoplasmic reticulum membrane | - |
Homo sapiens | 5789 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | Fe3+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + AH2 + O2 | Homo sapiens | - |
prostaglandin H2 + A + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.1 | Homo sapiens | - |
a homology modeling structure of human PGHS-1 is constructed using the Swiss-Model server and the ovine crystal structure 1Q4G as template | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.99.1 | arachidonate + AH2 + O2 | - |
Homo sapiens | prostaglandin H2 + A + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.1 | COX1 | - |
Homo sapiens |
| 1.14.99.1 | PGHS | - |
Homo sapiens |
| 1.14.99.1 | PGHS-1 | - |
Homo sapiens |
| 1.14.99.1 | prostaglandin endoperoxide H synthase-1 | - |
Homo sapiens |
| 1.14.99.1 | prostaglandin endoperoxide synthase | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.99.1 | 7.8 | - |
enzyme-linked immunoassay for PGE2 | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.99.1 | heme | - |
Homo sapiens | |
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