Literature summary extracted from

Zancan, P.; Rosas, A.O.; Marcondes, M.C.; Marinho-Carvalho, M.M.; Sola-Penna, M.
Clotrimazole inhibits and modulates heterologous association of the key glycolytic enzyme 6-phosphofructo-1-kinase (2007), Biochem. Pharmacol., 73, 1520-1527.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
2.7.1.11	Calmodulin	clotrimazole-inhibited enzyme can be activated by calmodulin	Oryctolagus cuniculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.1.11	clotrimazole	clotrimazole alone induces dimerization of the enzyme reducing the population of tetramers, which is not observed when calmodulin is also present. Since PFK dimers are less active than tetramers, this can explain the inhibitory effect of clotrimazole	Oryctolagus cuniculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.1.11	Oryctolagus cuniculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.1.11	skeletal muscle	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.1.11	ATP + D-fructose 6-phosphate	-	Oryctolagus cuniculus	ADP + D-fructose 1,6-bisphosphate	-	?

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Release 2023.1 (January 2023)