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Literature summary extracted from

  • Ghosh, S.S.; Lu, Y.; Lee, S.W.; Wang, X.; Guha, C.; Roy-Chowdhury, J.; Roy-Chowdhury, N.
    Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1) (2005), Biochem. J., 392, 685-692.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 UDP-GlcNAc stimulates Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 expression in COS7 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.17 C127C mutation results in loss of UGT1A1 activity Homo sapiens
2.4.1.17 C156R mutation results in loss of UGT1A1 activity Homo sapiens
2.4.1.17 C177Y mutation results in loss of UGT1A1 activity Homo sapiens
2.4.1.17 C186C although the activity of the C186Y mutant UGT1A1 is reduced to 50% of normal, the enzyme activity increases proportionately in the presence of UDPGlcNAc Homo sapiens
2.4.1.17 C186Y 45% of wild-type activity with bilirubin as substrate Homo sapiens
2.4.1.17 C223Y mutation results in loss of UGT1A1 activity Homo sapiens
2.4.1.17 C280Y mutation results in loss of UGT1A1 activity Homo sapiens
2.4.1.17 C384Y mutation results in loss of UGT1A1 activity Homo sapiens
2.4.1.17 C509Y 75% of wild-type activity with bilirubin as substrate Homo sapiens
2.4.1.17 C510Y 80% of wild-type activity with bilirubin as substrate Homo sapiens
2.4.1.17 C517Y 85% of wild-type activity with bilirubin as substrate Homo sapiens
2.4.1.17 Q357R mutation results in loss of UGT1A1 activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens P22309
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-glucuronate + bilirubin
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A1
-
 Homo sapiens