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Literature summary extracted from
- Superposition of a tRNASer acceptor stem microhelix into the seryl-tRNA synthetase complex (2007), Biochem. Biophys. Res. Commun., 362, 415-418.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 6.1.1.11 | tRNASer-seryl-tRNA synthetase complex, X-ray diffraction structure determination and analysis at 2.9 A resolution, the 1.8 A-resolution tRNASer acceptor stem crystal structure is superimposed to a 2.9 A-resolution crystal structure of a tRNASer-seryl-tRNA synthetase complex for a visualization of the binding environment of the tRNASer microhelix, modeling | Thermus thermophilus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.1.1.11 | Mg2+ | - |
Thermus thermophilus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.1.1.11 | ATP + L-serine + tRNASer | Thermus thermophilus | - |
AMP + diphosphate + L-seryl-tRNASer | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 6.1.1.11 | Thermus thermophilus | P34945 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 6.1.1.11 | ATP + L-serine + tRNASer | - |
Thermus thermophilus | AMP + diphosphate + L-seryl-tRNASer | - |
? | |
| 6.1.1.11 | ATP + L-serine + tRNASer | a two-step reaction, seryl-tRNA synthetase is a class II synthetase depending on rather few and simple identity elements in tRNASer to determine the amino acid specificity, tRNASer acceptor stem microhelices can be aminoacylated with serine as part of the tRNA a valuable tool for investigating the structural motifs in a tRNASer-seryl-tRNA synthetase complex, tRNASer secondary structure, overview | Thermus thermophilus | AMP + diphosphate + L-seryl-tRNASer | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 6.1.1.11 | SerRS | - |
Thermus thermophilus |
| 6.1.1.11 | Seryl-tRNA synthetase | - |
Thermus thermophilus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 6.1.1.11 | ATP | - |
Thermus thermophilus | |
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Release 2023.1 (January 2023)
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