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Literature summary extracted from

  • Fyrberg, A.; Albertioni, F.; Lotfi, K.
    Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes (2007), Biochem. Biophys. Res. Commun., 357, 847-853.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.113 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.74 additional information Homo sapiens enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies ?
-
 ?
2.7.1.113 ATP + 2'-deoxyguanosine Homo sapiens important enzyme for the phosphorylation/activation of 2'-deoxyguanosine ADP + 2'-deoxyguanosine 5'-phosphate
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-
2.7.1.113 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 CCRF-CEM cell enzyme activity increases up to 3fold when cells start to proliferate Homo sapiens
-
2.7.1.74 HL60 cell enzyme activity increases up to 3fold when cells start to proliferate Homo sapiens
-
2.7.1.74 K-562 cell
-
 Homo sapiens
-
2.7.1.74 MOLT-4 cell enzyme activity increases up to 3fold when cells start to proliferate Homo sapiens
-
2.7.1.113 CCRF-CEM cell 3fold increase when cells start to proliferate Homo sapiens
-
2.7.1.113 CEM cell
-
 Homo sapiens
-
2.7.1.113 HL-60 cell
-
 Homo sapiens
-
2.7.1.113 HL-60 cell 3fold increase when cells start to proliferate Homo sapiens
-
2.7.1.113 K-562 cell
-
 Homo sapiens
-
2.7.1.113 K-562 cell no increase in activity when cells proliferate Homo sapiens
-
2.7.1.113 MOLT-4 cell
-
 Homo sapiens
-
2.7.1.113 MOLT-4 cell 3fold increase when cells start to proliferate Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
2.7.1.74 additional information enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies Homo sapiens ?
-
 ?
2.7.1.113 ATP + 2'-deoxyguanosine
-
 Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
 ?
2.7.1.113 ATP + 2'-deoxyguanosine important enzyme for the phosphorylation/activation of 2'-deoxyguanosine Homo sapiens ADP + 2'-deoxyguanosine 5'-phosphate
-
 ir
2.7.1.113 ATP + deoxyguanosine
-
 Homo sapiens ADP + dGMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Homo sapiens
2.7.1.113 DGK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.113 ATP
-
 Homo sapiens