BRENDA - Enzyme Database show

Cell cycle effect on the activity of deoxynucleoside analogue metabolising enzymes

Fyrberg, A.; Albertioni, F.; Lotfi, K.; Biochem. Biophys. Res. Commun. 357, 847-853 (2007)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.113
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
additional information
Homo sapiens
enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies
?
-
-
-
2.7.1.113
ATP + 2'-deoxyguanosine
Homo sapiens
important enzyme for the phosphorylation/activation of 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
ir
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
2.7.1.113
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
CCRF-CEM cell
enzyme activity increases up to 3fold when cells start to proliferate
Homo sapiens
-
2.7.1.74
HL60 cell
enzyme activity increases up to 3fold when cells start to proliferate
Homo sapiens
-
2.7.1.74
K-562 cell
-
Homo sapiens
-
2.7.1.74
MOLT-4 cell
enzyme activity increases up to 3fold when cells start to proliferate
Homo sapiens
-
2.7.1.113
CCRF-CEM cell
3fold increase when cells start to proliferate
Homo sapiens
-
2.7.1.113
CEM cell
-
Homo sapiens
-
2.7.1.113
HL-60 cell
; 3fold increase when cells start to proliferate
Homo sapiens
-
2.7.1.113
K-562 cell
; no increase in activity when cells proliferate
Homo sapiens
-
2.7.1.113
MOLT-4 cell
; 3fold increase when cells start to proliferate
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
671801
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
additional information
enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies
671801
Homo sapiens
?
-
-
-
-
2.7.1.113
ATP + 2'-deoxyguanosine
-
671801
Homo sapiens
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.113
ATP + 2'-deoxyguanosine
important enzyme for the phosphorylation/activation of 2'-deoxyguanosine
671801
Homo sapiens
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
ir
2.7.1.113
ATP + deoxyguanosine
-
671801
Homo sapiens
ADP + dGMP
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.113
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.113
ATP
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.113
mitochondrion
-
Homo sapiens
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.74
additional information
Homo sapiens
enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies
?
-
-
-
2.7.1.113
ATP + 2'-deoxyguanosine
Homo sapiens
important enzyme for the phosphorylation/activation of 2'-deoxyguanosine
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
ir
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.7.1.74
CCRF-CEM cell
enzyme activity increases up to 3fold when cells start to proliferate
Homo sapiens
-
2.7.1.74
HL60 cell
enzyme activity increases up to 3fold when cells start to proliferate
Homo sapiens
-
2.7.1.74
K-562 cell
-
Homo sapiens
-
2.7.1.74
MOLT-4 cell
enzyme activity increases up to 3fold when cells start to proliferate
Homo sapiens
-
2.7.1.113
CCRF-CEM cell
3fold increase when cells start to proliferate
Homo sapiens
-
2.7.1.113
CEM cell
-
Homo sapiens
-
2.7.1.113
HL-60 cell
; 3fold increase when cells start to proliferate
Homo sapiens
-
2.7.1.113
K-562 cell
; no increase in activity when cells proliferate
Homo sapiens
-
2.7.1.113
MOLT-4 cell
; 3fold increase when cells start to proliferate
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
671801
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
additional information
enzyme of the salvage pathway for deoxyribonucleotide synthesis, which provides resting cells with deoxynucleotides for DNA repair and mitochondrial DNA synthesis, important enzyme for the phosphorylation/activation of deoxynucleoside analogues, which are cytotoxic towards both replicating and indolent malignancies
671801
Homo sapiens
?
-
-
-
-
2.7.1.113
ATP + 2'-deoxyguanosine
-
671801
Homo sapiens
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.113
ATP + 2'-deoxyguanosine
important enzyme for the phosphorylation/activation of 2'-deoxyguanosine
671801
Homo sapiens
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
ir
2.7.1.113
ATP + deoxyguanosine
-
671801
Homo sapiens
ADP + dGMP
-
-
-
?