Literature summary extracted from

Im, K.R.; Jeong, T.S.; Kwon, B.M.; Baek, N.I.; Kim, S.H.; Kim, D.K.
Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda (2006), Arch. Pharm. Res., 29, 191-194.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.26	betulin	IC50: 0.083 mM, hACAT-1	Homo sapiens
2.3.1.26	lupeol	IC50: 0.048 mM, hACAT-1	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.26	Homo sapiens	O75908	-	-
2.3.1.26	Homo sapiens	P35610	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.26	oleoyl-CoA + cholesterol	-	Homo sapiens	CoA + cholesteryl oleate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.26	hACAT-1	-	Homo sapiens
2.3.1.26	hACAT-2	-	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.3.1.26	0.048	-	IC50: 0.048 mM, hACAT-1	Homo sapiens	lupeol
2.3.1.26	0.083	-	IC50: 0.083 mM, hACAT-1	Homo sapiens	betulin

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Release 2023.1 (January 2023)