Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Handschin, C.; Gnerre, C.; Fraser, D.J.; Martinez-Jimenez, C.; Jover, R.; Meyer, U.A.
    Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids (2005), Arch. Biochem. Biophys., 434, 75-85.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.23 gene CYP7A1, DNA sequence determination and analysis, phylogenetic tree, expression analysis and regulation, overview Gallus gallus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.23 additional information ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, molecular mechanisms underlying CYP7A1 inhibition, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.23 microsome
-
 Gallus gallus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Gallus gallus the gene encoding CYP7A1 is tightly regulated in order to control intrahepatic cholesterol and bile acid levels, ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression, overview 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.23 Gallus gallus Q5ILH2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.23 hepatocyte
-
 Gallus gallus
-
1.14.14.23 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Gallus gallus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.23 cholesterol + [reduced NADPH-hemoprotein reductase] + O2 the gene encoding CYP7A1 is tightly regulated in order to control intrahepatic cholesterol and bile acid levels, ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression, bile acids regulate CYP7A1 via small heterodimer partner and liver receptor homolog-1, drugs repress chicken hepatic nuclear factor 4alpha transcript levels concomitant with a reduction in CYP7A1 expression, overview Gallus gallus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.23 cholesterol 7alpha-hydroxylase
-
 Gallus gallus
1.14.14.23 CYP7A1
-
 Gallus gallus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.23 NADPH
-
 Gallus gallus