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Literature summary extracted from

  • Roberts, S.C.; Jiang, Y.; Gasteier, J.; Frydman, B.; Marton, L.J.; Heby, O.; Ullman, B.
    Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs (2007), Antimicrob. Agents Chemother., 51, 438-445.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.16 overexpression of the enzyme in strain clone DI700 episomes Leishmania donovani

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.16 additional information a strain overexpressing the enzyme shows a high level of resistance to n-butylamine, overview Leishmania donovani

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 Berenil
-
 Leishmania donovani
2.5.1.16 CGC-11038 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11098 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11099 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11108 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11114 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11121 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11122 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11144 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11150 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11157 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11158 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11159 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11160 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11172 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11175 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11207 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11211 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11217 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11226 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11227 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11231 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11235 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11237 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11239 polyamine analogue Leishmania donovani
2.5.1.16 CGC-11241 polyamine analogue Leishmania donovani
2.5.1.16 mitoguazone
-
 Leishmania donovani
2.5.1.16 additional information inhibitory potency of diverse polyamine analogues on the polyamine biosynthesis in wild-type strain and strains overexpressing polyamine biosynthetic enzymes, EC50 values, overview Leishmania donovani
2.5.1.16 n-butylamine specific inhibitor of the enzyme in vivo and in vitro Leishmania donovani
2.5.1.16 Pentamidine
-
 Leishmania donovani

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.16 additional information episome Leishmania donovani
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.16 S-adenosylmethioninamine + putrescine Leishmania donovani polyamine biosynthetic enzyme 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.16 Leishmania donovani
-
 clone DI700
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.16 S-adenosylmethioninamine + putrescine
-
 Leishmania donovani 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosylmethioninamine + putrescine polyamine biosynthetic enzyme Leishmania donovani 5'-S-methyl-5'-thioadenosine + spermidine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.16 SPDSYN
-
 Leishmania donovani
2.5.1.16 spermidine synthase
-
 Leishmania donovani