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Literature summary extracted from

  • Ngo, S.C.; Zimhony, O.; Chung, W.J.; Sayahi, H.; Jacobs, W.R.; Welch, J.T.
    Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs (2007), Antimicrob. Agents Chemother., 51, 2430-2435.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 5-chloropyrazinamide IC50: 0.151 mM Mycobacterium tuberculosis
2.3.1.85 Benzamide 100 mM, 15% inhibition Mycobacterium tuberculosis
2.3.1.85 cerulenin no inhibitory at 3 mM, 62% inhibition at 6.0 mM Mycobacterium tuberculosis
2.3.1.85 Pyrazinamide IC50: 8.9 mM Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.85 recombinant Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Mycobacterium tuberculosis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.85 FASI
-
 Mycobacterium tuberculosis
2.3.1.85 fatty acid synthase I
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.85 NADPH
-
 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.1.85 0.055 0.059 5-chloropyrazinamide 37°C, pH 7.4 Mycobacterium tuberculosis
2.3.1.85 2.6
-
 Pyrazinamide 37°C, pH 7.4 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.85 0.151
-
 IC50: 0.151 mM Mycobacterium tuberculosis 5-chloropyrazinamide
2.3.1.85 8.9
-
 IC50: 8.9 mM Mycobacterium tuberculosis Pyrazinamide