Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ramachandran, V.; Chandrakala, B.; Kumar, V.P.; Usha, V.; Solapure, S.M.; de Sousa, S.M.
    Screen for inhibitors of the coupled transglycosylase-transpeptidase of peptidoglycan biosynthesis in Escherichia coli (2006), Antimicrob. Agents Chemother., 50, 1425-1432.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.129 activity of PBP1a or PBP1b can be measured in membranes by cloning the PBP into an Escherichia coli ponB::Spcr strain Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.129 Moenomycin coupled transglycosylasetranspeptidase Escherichia coli
2.4.1.129 nisin
-
 Escherichia coli
2.4.1.129 penicillin coupled transglycosylasetranspeptidase Escherichia coli
2.4.1.129 tunicamycin
-
 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.129 membrane
-
 Escherichia coli 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.129 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.129 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol PBP1a and PBP1b have both transglycosylase and transpeptidase activity Escherichia coli [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.129 PBP1a the enzyme has both transglycosylase and transpeptidase activity Escherichia coli
2.4.1.129 PBP1b the enzyme has both transglycosylase and transpeptidase activity Escherichia coli
2.4.1.129 penicillin-binding protein 1a the enzyme has both transglycosylase and transpeptidase activity Escherichia coli
2.4.1.129 penicillin-binding protein 1B the enzyme has both transglycosylase and transpeptidase activity Escherichia coli