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Literature summary extracted from

  • Nieman, K.M.; Hartz, C.S.; Szegedi, S.S.; Garrow, T.A.; Sparks, J.D.; Schalinske, K.L.
    Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats (2006), Am. J. Physiol. Endocrinol. Metab., 291, E1235-E1242.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.5 medicine upregulation of BHMT may indicate an increased choline requirement in the diabetic rat Rattus norvegicus
2.1.1.20 medicine diabetes increases the activity and abundance of GNMT, lack of dietary folate results in the highest activity of GNMT in diabetic rats without the abundance of the protein being altered Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.20 additional information folate-containing diets attenuate GNMT activity in diabetic rats but are without effect on abundance Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.5 Rattus norvegicus
-
-
-
2.1.1.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.5 liver BHMT mRNA and activity increases about 2fold in diabetic rats compared with the nondiabetic animals Rattus norvegicus
-
2.1.1.20 liver activity of GNMT is increased about 2fold in diabetic liver Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.5 L-homocysteine + betaine folate-independent remethylation of homocysteine Rattus norvegicus L-methionine + dimethylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + sarcosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.5 BHMT
-
 Rattus norvegicus
2.1.1.20 GNMT
-
 Rattus norvegicus