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Literature summary extracted from

  • Leiber, D.; Banno, Y.; Tanfin, Z.
    Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms (2007), Am. J. Physiol., 292, C240-C250.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.91 endothelin-1 1 nM, 2.4fold and 2.7fold increase of activity after 5 and 10 min, respectively Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 dimethylsphingosine 0.01 mM Rattus norvegicus
2.7.1.91 DL-threo-dihydrosphingosine 0.002 mM Rattus norvegicus
2.7.1.91 additional information not inhibited by 0.25% Triton X-100 Rattus norvegicus
2.7.1.91 Ro-31-8220
-
 Rattus norvegicus
2.7.1.91 U-73122
-
 Rattus norvegicus
2.7.1.91 Y-27632
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Rattus norvegicus Q91V26
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 myometrium
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Rattus norvegicus ADP + sphingosine 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 sphinganine kinase
-
 Rattus norvegicus
2.7.1.91 SPHK1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.91 0.0002
-
 at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus Ro-31-8220
2.7.1.91 0.00055
-
 at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus U-73122
2.7.1.91 0.0021
-
 at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus Y-27632
2.7.1.91 0.0024
-
 at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus DL-threo-dihydrosphingosine
2.7.1.91 0.0024
-
 at 37°C, in the presence of 0.25% Triton X-100 Rattus norvegicus dimethylsphingosine