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Literature summary extracted from
- TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation (2006), Am. J. Physiol., 290, C964-C971.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.6.3.1 | TNF-alpha | activation of enzyme, resulting in an increase in intracellular H2O2 that stimulates Ca2+ sparks and transient Kca currents, leading to a reduction in global concentration of Ca2+ and vasodilation | Rattus norvegicus |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.6.3.1 | medicine | TNF-alpha activates enzyme, resulting in an increase in intracellular H2O2 that stimulates Ca2+ sparks and transient Kca currents, leading to a reduction in global concentration of Ca2+ and vasodilation | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.6.3.1 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.6.3.1 | smooth muscle | - |
Rattus norvegicus | - |
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Release 2023.1 (January 2023)
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