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Literature summary extracted from
- Snake venom fibrin(ogen)olytic enzymes (2005), Toxicon, 45, 1021-1039.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.72 | medicine | treatment of occlusive thrombi | Agkistrodon contortrix |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.72 | 1,10-phenanthroline | complete and rapid inhibition | Agkistrodon contortrix |  |
| 3.4.24.72 | 1,10-phenanthroline | - |
Bothrops neuwiedi | |
| 3.4.24.72 | DTT | - |
Agkistrodon contortrix | |
| 3.4.24.72 | EDTA | - |
Agkistrodon contortrix | |
| 3.4.24.72 | EDTA | - |
Bothrops neuwiedi | |
| 3.4.24.72 | EDTA | - |
Gloydius halys | |
| 3.4.24.72 | o-phenanthroline | - |
Gloydius halys | |
| 3.4.24.72 | Tetraethylenepentamine | complete and rapid inhibition | Agkistrodon contortrix | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.72 | 0.000000242 | - |
low molecular weight kininogen | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000113 | - |
His-Thr-Glu-Phe-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000138 | - |
Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000164 | - |
His-Thr-Glu-Glu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000247 | - |
His-Thr-Glu-Lys-Phe-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000338 | - |
His-Thr-Glu-Arg-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000391 | - |
His-Thr-Glu-Pro-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000415 | - |
His-Thr-Glu-His-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000528 | - |
His-Thr-Glu-Leu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000579 | - |
His-Thr-Glu-Lys-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000739 | - |
His-Thr-Glu-Ala-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000832 | - |
His-Thr-Glu-Ser-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.00000937 | - |
His-Thr-Glu-Asn-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.0000654 | - |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.000579 | - |
His-Thr-Glu-Lys-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.72 | 22520 | - |
calculated molecular weight | Bothrops neuwiedi |
| 3.4.24.72 | 22710 | - |
- |
Agkistrodon contortrix |
| 3.4.24.72 | 22710 | - |
calculated molecular weight | Gloydius halys |
| 3.4.24.72 | 23000 | - |
MALDI-TOF mass spectrometry | Agkistrodon contortrix |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.72 | Agkistrodon contortrix | - |
subspecies Agkistrodon contortrix contortrix | - |
| 3.4.24.72 | Bothrops neuwiedi | - |
- |
- |
| 3.4.24.72 | Gloydius halys | - |
Agkistrodon halys brevicaudus | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.72 | hydrophobic interaction high performance liquid chromatography, hydroxyapatite high performance liquid chromatography and cation exchange high performance liquid chromatography | Agkistrodon contortrix |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.72 | venom | - |
Gloydius halys | - |
| 3.4.24.72 | venom | - |
Bothrops neuwiedi | - |
| 3.4.24.72 | venom | - |
Agkistrodon contortrix | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.72 | Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg + H2O | - |
Agkistrodon contortrix | Arg-Pro-Pro-Gly-Phe-Ser-Pro + Phe-Arg | - |
ir | |
| 3.4.24.72 | Fibrin + H2O | - |
Gloydius halys | ? | - |
? | |
| 3.4.24.72 | Fibrin + H2O | - |
Bothrops neuwiedi | ? | - |
? | |
| 3.4.24.72 | Fibrin + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | Fibrinogen + H2O | - |
Gloydius halys | ? | - |
? | |
| 3.4.24.72 | Fibrinogen + H2O | - |
Bothrops neuwiedi | ? | - |
? | |
| 3.4.24.72 | Fibrinogen + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Ala-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Arg-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Asn-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Glu-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-His-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Leu-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Ala-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Arg-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Asn-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Glu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-His-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Phe-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Pro-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Lys-Ser-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Phe-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Pro-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | His-Thr-Glu-Ser-Leu-Val-Thr-Ser + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val + H2O | - |
Agkistrodon contortrix | ? | - |
? | |
| 3.4.24.72 | low molecular weight kininogen + H2O | - |
Agkistrodon contortrix | kallidin + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.72 | brevilysin L6 | - |
Gloydius halys |
| 3.4.24.72 | neuwiedase | - |
Bothrops neuwiedi |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.72 | 37 | - |
- |
Bothrops neuwiedi |
| 3.4.24.72 | 37 | - |
- |
Agkistrodon contortrix |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.72 | additional information | - |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.0086 | - |
low molecular weight kininogen | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.09 | - |
Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.16 | - |
His-Thr-Glu-Leu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.2 | - |
His-Thr-Glu-Lys-Phe-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.45 | - |
His-Thr-Glu-Phe-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 0.46 | - |
His-Thr-Glu-Glu-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 1.59 | - |
His-Thr-Glu-Pro-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 1.97 | - |
His-Thr-Glu-Arg-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 2.23 | - |
His-Thr-Glu-Lys-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 3.98 | - |
His-Thr-Glu-Ser-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 5 | - |
His-Thr-Glu-Ala-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 5.19 | - |
His-Thr-Glu-His-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 6.03 | - |
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | - |
Agkistrodon contortrix | |
| 3.4.24.72 | 65.7 | - |
His-Thr-Glu-Asn-Leu-Val-Thr-Ser | - |
Agkistrodon contortrix | |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.72 | 7.1 | 7.4 | - |
Agkistrodon contortrix |
| 3.4.24.72 | 7.4 | 8 | - |
Bothrops neuwiedi |
| 3.4.24.72 | 8.5 | 9.5 | - |
Gloydius halys |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 3.4.24.72 | Gloydius halys | - |
- |
4.8 |
| 3.4.24.72 | Bothrops neuwiedi | - |
- |
5.9 |
| 3.4.24.72 | Agkistrodon contortrix | - |
- |
6.8 |
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