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Literature summary extracted from

  • Vafiadi, C.; Topakas, E.; Wong, K.K.Y.; Suckling, I.D.; Christakopoulos, P.
    Mapping the hydrolytic and synthetic selectivity of a type C feruloyl esterase (StFaeC) from Sporotrichum thermophile using alkyl ferulates (2005), Tetrahedron, 16, 373-379.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.1.1.73 medicine potential use for providing ferulic acid as precursor for the synthesis of cinnamic acid and its derivatives as anti-cancer drugs and for antimicrobial, antiviral and anti-inflammatory agents Thermothelomyces heterothallicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.73 0.1
-
 iso-propyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 0.16
-
 2-butyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 0.19
-
 iso-butyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 0.51
-
 ethyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 0.51
-
 n-propyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 0.73
-
 n-butyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 1.64
-
 methyl ferulate hydrolysis Thermothelomyces heterothallicus
3.1.1.73 3 3.2 L-arabinose transesterification in a n-hexane/t-butanol/water solvent system, 35°C Thermothelomyces heterothallicus
3.1.1.73 68.9
-
 methyl ferulate transesterification in a n-hexane/t-butanol/water solvent system, 35°C Thermothelomyces heterothallicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.73 extracellular
-
 Thermothelomyces heterothallicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.73 feruloyl polysaccharide + H2O Thermothelomyces heterothallicus involved in the degradation of plant cell wall material, breaks ferulic acid cross-links between cell wall components ferulic acid + diferulic acid + ?
-
 ?

Organic Solvent Stability

EC Number Organic Solvent Comment Organism
3.1.1.73 n-hexane n-hexane/t-butanol/water, suitable solvent for transesterification Thermothelomyces heterothallicus
3.1.1.73 t-butanol n-hexane/t-butanol/water, suitable solvent for transesterification Thermothelomyces heterothallicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.73 Thermothelomyces heterothallicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.73 2-butyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + 2-butanol
-
 ?
3.1.1.73 ethyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + ethanol
-
 ?
3.1.1.73 feruloyl polysaccharide + H2O involved in the degradation of plant cell wall material, breaks ferulic acid cross-links between cell wall components Thermothelomyces heterothallicus ferulic acid + diferulic acid + ?
-
 ?
3.1.1.73 iso-butyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + iso-butanol
-
 ?
3.1.1.73 iso-propyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + iso-propanol
-
 ?
3.1.1.73 methyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + methanol
-
 ?
3.1.1.73 methyl ferulate + L-arabinose 40% transesterification after 160 h Thermothelomyces heterothallicus L-arabinosyl ferulate + methanol
-
 ?
3.1.1.73 additional information the other substrates tested for hydrolysis show transesterification at rates between 2.7 and 6.3% Thermothelomyces heterothallicus ?
-
 ?
3.1.1.73 n-butyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + n-butanol
-
 ?
3.1.1.73 n-propyl ferulate + H2O
-
 Thermothelomyces heterothallicus ferulic acid + n-propanol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.73 StFaeC
-
 Thermothelomyces heterothallicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.73 35
-
 transesterification Thermothelomyces heterothallicus
3.1.1.73 55
-
 hydrolytic activity Thermothelomyces heterothallicus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.1.73 45
-
 unstable above 45°C when incubated at pH 6.0 for 6 h Thermothelomyces heterothallicus