Literature summary extracted from

Farina, M.G.; Billi, S.; Sordelli, M.S.; Ribeiro, M.L.; Di Girolamo, G.; Lombardi, E.; Franchi, A.M.
Nitric oxide (NO) inhibits prostaglandin E2 9-ketoreductase (9-KPR) activity in human fetal membranes (2006), Prostaglandins Other Lipid Mediat., 79, 260-270.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
1.1.1.189	additional information	aminoguanidine, an inducible nitric oxide synthase inhibitor, does not affect the enzyme, but activates L-NAME, a non-selective nitric oxide synthase inhibitor, thereby increasing prostaglandin F2alpha synthesis	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.189	nitric oxide	inhibition e.g. by NOC-18, a NO donor	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.1.1.189	membrane	fetal	Homo sapiens	16020	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.189	prostaglandin E2 + NADPH + H+	Homo sapiens	-	prostaglandin F2alpha + NADP+	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.189	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.189	chorioamnion	-	Homo sapiens	-
1.1.1.189	fetus	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.189	prostaglandin E2 + NADPH + H+	-	Homo sapiens	prostaglandin F2alpha + NADP+	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.189	9-KPR	-	Homo sapiens
1.1.1.189	prostaglandin E2 9-ketoreductase	-	Homo sapiens

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.1.1.189	37	-	assay at	Homo sapiens

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.1.1.189	7.4	-	assay at	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.189	NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)