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Literature summary extracted from

  • Lin, S.X.; Shi, R.; Qiu, W.; Azzi, A.; Zhu, D.W.; Dabbagh, H.A.; Zhou, M.
    Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5 (2006), Mol. Cell. Endocrinol., 248, 38-46.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.62 0.00003
-
 estrone wild-type enzyme Homo sapiens
1.1.1.62 0.0003
-
 estrone mutant enzyme L149V Homo sapiens
1.1.1.62 0.0043
-
 dihydrotestosterone mutant enzyme L149V Homo sapiens
1.1.1.62 0.0046
-
 estradiol-17beta wild-type enzyme Homo sapiens
1.1.1.62 0.01
-
 estradiol-17beta mutant enzyme L149V Homo sapiens
1.1.1.62 0.0172
-
 dehydroepiandrosterone mutant enzyme L149V Homo sapiens
1.1.1.62 0.033
-
 dihydrotestosterone wild-type enzyme Homo sapiens
1.1.1.62 0.045
-
 dehydroepiandrosterone wild-type enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 dehydroepiandrosterone + NADP+
-
 Homo sapiens ?
-
 ?
1.1.1.62 dihydrotestosterone + NAD(P)H + H+
-
 Homo sapiens androstane-3beta,17beta-diol + NAD(P)+
-
 ?
1.1.1.62 estrone + NAD(P)H + H+
-
 Homo sapiens estradiol-17beta + NAD(P)+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.62 17beta-HSD1
-
 Homo sapiens
1.1.1.62 17beta-hydroxysteroid dehydrogenase types 1
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.62 0.12
-
 dehydroepiandrosterone mutant enzyme L149V Homo sapiens
1.1.1.62 0.16
-
 dehydroepiandrosterone wild-type enzyme Homo sapiens
1.1.1.62 0.24
-
 estradiol-17beta mutant enzyme L149V Homo sapiens
1.1.1.62 0.26
-
 estrone mutant enzyme L149V Homo sapiens
1.1.1.62 0.33
-
 dihydrotestosterone wild-type enzyme Homo sapiens
1.1.1.62 0.34
-
 dihydrotestosterone mutant enzyme L149V Homo sapiens
1.1.1.62 4.4
-
 estradiol-17beta wild-type enzyme Homo sapiens
1.1.1.62 5.8
-
 estrone wild-type enzyme Homo sapiens