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Literature summary extracted from

  • Mintz, K.P.; Moskovitz, J.; Wu, H.; Fives-Taylor, P.M.
    Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus actinomycetemcomitans (2002), Microbiology, 148, 3695-3703.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 gene msrA, DNA and amino acid sequence determination and analysis Aggregatibacter actinomycetemcomitans

Protein Variants

EC Number Protein Variants Comment Organism
1.8.4.11 additional information msrA gene inactivation by chromosomal insertion via allele replacement mutagenesis does not lead to increased sensitivity against oxidative stress but to complete loss of enzymatic activity with synthetic substrates Aggregatibacter actinomycetemcomitans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.11 cytosol subcellular localization analysis, overview Aggregatibacter actinomycetemcomitans 5829
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 additional information Aggregatibacter actinomycetemcomitans the enzyme is not a major virulence determinant in the oral pathogen, MsrA is required for protein repair and protection against oxidative damage as well as for the proper expression or maintenance of functional adhesins ?
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Aggregatibacter actinomycetemcomitans stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Aggregatibacter actinomycetemcomitans Q9AL99 strains VT1169 and VT1530 derived from the clinical strain SUNY 465
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 dabsyl-L-methionine-(S)-S-oxide + DTT stereospecific reduction Aggregatibacter actinomycetemcomitans dabsyl-L-methionine + DTT disulfide + H2O
-
 ?
1.8.4.11 additional information the enzyme is not a major virulence determinant in the oral pathogen, MsrA is required for protein repair and protection against oxidative damage as well as for the proper expression or maintenance of functional adhesins Aggregatibacter actinomycetemcomitans ?
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Aggregatibacter actinomycetemcomitans peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 MsrA
-
 Aggregatibacter actinomycetemcomitans
1.8.4.11 peptide methionine sulfoxide reductase
-
 Aggregatibacter actinomycetemcomitans

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.4.11 37
-
 assay at Aggregatibacter actinomycetemcomitans

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.4.11 7.4
-
 assay at Aggregatibacter actinomycetemcomitans

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 dithiothreitol
-
 Aggregatibacter actinomycetemcomitans