Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Pau, A.; Asproni, B.; Murineddu, G.; Boatto, G.; Grella, G.E.; Rakowitz, D.; Costantino, L.; Pinna, G.A.
    Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors (2006), Med. Chem., 2, 39-45.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.21 8-bromo-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid 4fold decreased inhibitory potency compared to the nonsubstituted parent compound Bos taurus
1.1.1.21 8-chloro-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid 4fold decreased inhibitory potency compared to the nonsubstituted parent compound Bos taurus
1.1.1.21 8-methyl-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid 2fold decreased inhibitory potency compared to the nonsubstituted parent compound Bos taurus
1.1.1.21 thienocinnolinone alkanoic acid derivatives i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 lens
-
 Bos taurus
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Bos taurus
1.1.1.21 ALR2
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.21 0.0314
-
 i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview Bos taurus thienocinnolinone alkanoic acid derivatives