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Literature summary extracted from

  • Marx, P.F.; Havik, S.R.; Bouma, B.N.; Meijers, J.C.
    Role of isoleucine residues 182 and 183 in thrombin-activatable fibrinolysis inhibitor (2005), J. Thromb. Haemost., 3, 1293-1300.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.20 I182R site-directed mutagenesis, the mutant shows reduced activition by thrombin but similar fibrinogen and plasminogen binding capacitiy compared to the wild-type enzyme Homo sapiens
3.4.17.20 I183E site-directed mutagenesis, the mutant shows reduced activition by thrombin but similar fibrinogen and plasminogen binding capacitiy compared to the wild-type enzyme Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.20 Ca2+ required for activation of the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.20 additional information Homo sapiens the enzyme is involved in blood clot lysis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.20 Homo sapiens
-
 isozyme T147/T325
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.20 proteolytic modification Ca2+-dependent activation by thrombin/thrombumodulin or plasmin by cleavage of the activation peptide Homo sapiens

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.17.20 additional information
-
 plasminogen and fibrinogen binding activity of the enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.20 hippuryl-L-arginine + H2O
-
 Homo sapiens hippuric acid + L-arginine
-
 ?
3.4.17.20 additional information the enzyme is involved in blood clot lysis Homo sapiens ?
-
 ?
3.4.17.20 additional information the enzyme binds to plasminogen and fibrinogen Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.20 Procarboxypeptidase B
-
 Homo sapiens
3.4.17.20 procarboxypeptidase R
-
 Homo sapiens
3.4.17.20 procarboxypeptidase U
-
 Homo sapiens
3.4.17.20 TAFI
-
 Homo sapiens
3.4.17.20 thrombin activatable fibrinolysis inhibitor
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.20 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.20 7.4
-
 assay at Homo sapiens