Literature summary extracted from

Latacha, M.P.; Schaiff, W.T.; Eisenberg, P.R.; Abendschein, D.R.
Factor XII-dependent increases in thrombin activity induce carboxypeptidase-mediated attenuation of pharmacological fibrinolysis (2004), J. Thromb. Haemost., 2, 128-134.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.21.38	streptokinase SK	enzyme activity in plasma increases 2fold over 60 min in patients treated with fibrinolytic agents, tissue plasminogen activator t-PA or with streptokinase SK	Homo sapiens
3.4.21.38	tissue plasminogen activator t-PA	enzyme activity in plasma increases 2fold over 60 min in patients treated with fibrinolytic agents, tissue plasminogen activator t-PA or with streptokinase SK	Homo sapiens

Application

EC Number	Application	Comment	Organism
3.4.21.38	medicine	activation of factor XIIa increase thrombin generation, which promotes thrombin-activated fibrinolysis inhibitor TAFIa-mediated attenuation of fibrinolysis	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.38	Homo sapiens	-	patients treated with fibrinolytic agents	-

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Release 2023.1 (January 2023)