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Literature summary extracted from

  • Liu, H.; Robert, A.; Luu-The, V.
    Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme (2005), J. Steroid Biochem. Mol. Biol., 94, 173-179.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.51 DNA and amino acid sequence determination and analysis, chromosome metaphase, interphase mapping, i.e. FISH mapping, localization on chromosome 10q11.2, stable expression in HEK-293 cells Homo sapiens
1.1.1.62
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 dihydrotestosterone + NADPH + H+ Homo sapiens androsterone inactivation 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 estrone + NADPH Homo sapiens estrogen activation estradiol + NADP+
-
 ?
1.1.1.51 additional information Homo sapiens the isozyme might play an imporant role in modulation of active hormone levels in estrogen-sensitive cells or tissues ?
-
 ?
1.1.1.51 zymosterone + NADPH Homo sapiens
-
 zymosterol + NADP+
-
 ?
1.1.1.62 5alpha-dihydrotestosterone + NADP+ Homo sapiens the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells 5alpha-androstan-3,17-dione + NADPH
-
 ?
1.1.1.62 estrone + NAD(P)H Homo sapiens the enzyme produces active estradiol for cell proliferation estradiol-17beta + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-
1.1.1.62 Homo sapiens Q5MGS6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 liver
-
 Homo sapiens
-
1.1.1.62 placenta
-
 Homo sapiens
-
1.1.1.62 prostate gland
-
 Homo sapiens
-
1.1.1.62 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 dihydrotestosterone + NADPH + H+ androsterone inactivation Homo sapiens 5alpha-androstane-3beta,17beta-diol + NADP+
-
 ?
1.1.1.51 estrone + NADPH estrogen activation Homo sapiens estradiol + NADP+
-
 ?
1.1.1.51 additional information the isozyme might play an imporant role in modulation of active hormone levels in estrogen-sensitive cells or tissues Homo sapiens ?
-
 ?
1.1.1.51 zymosterone + NADPH
-
 Homo sapiens zymosterol + NADP+
-
 ?
1.1.1.62 5alpha-dihydrotestosterone + NADP+
-
 Homo sapiens 5alpha-androstan-3,17-dione + NADPH
-
 ?
1.1.1.62 5alpha-dihydrotestosterone + NADP+ the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells Homo sapiens 5alpha-androstan-3,17-dione + NADPH
-
 ?
1.1.1.62 estrone + NAD(P)H the enzyme produces active estradiol for cell proliferation Homo sapiens estradiol-17beta + NAD(P)+
-
 ?
1.1.1.62 estrone + NAD(P)H + H+
-
 Homo sapiens estradiol-17beta + NAD(P)+
-
 ?
1.1.1.62 zymosterone + NAD(P)H
-
 Homo sapiens zymosterol + NAD(P)+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD7_2
-
 Homo sapiens
1.1.1.51 form 2 type 7 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.62 17beta-HSD7 2
-
 Homo sapiens
1.1.1.62 form 2 type 7 17beta-hydroxysteroid dehydrogenase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADPH
-
 Homo sapiens