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Literature summary extracted from
- Receptor/gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate carboxykinase regulation in rat liver (2004), J. Pharmacol. Exp. Ther., 309, 328-339.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.32 | additional information | methylprednisolone induces enzyme expressions via cAMP | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.32 | ITP + oxaloacetate | Rattus norvegicus | rate limiting enzyme of gluconeogenesis | IDP + phosphoenolpyruvate + CO2 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.32 | Rattus norvegicus | - |
male Wistar rats, enzyme activity is stimulated by intravenous doses of methylprednisolone | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.32 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.32 | ITP + oxaloacetate | - |
Rattus norvegicus | IDP + phosphoenolpyruvate + CO2 | - |
? | |
| 4.1.1.32 | ITP + oxaloacetate | rate limiting enzyme of gluconeogenesis | Rattus norvegicus | IDP + phosphoenolpyruvate + CO2 | - |
? | |
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Release 2023.1 (January 2023)
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