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Literature summary extracted from

  • Marr, R.A.; Guan, H.; Rockenstein, E.; Kindy, M.; Gage, F.H.; Verma, I.; Masliah, E.; Hersh, L.B.
    Neprilysin regulates amyloid Beta peptide levels (2004), J. Mol. Neurosci., 22, 5-11.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.24.11 medicine neprilysin can reduce the size and number of Abeta deposits in a transgenic mouse model. Neprilysin gene transfer therapy or other methods to increase endogenous neprilysin activity have the potential to prevent the accumulation of the amyloid Abeta peptide and as such may be able to prevent or delay the onset of Alzheimer#s disease Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.11 phosphoramidon
-
 Mus musculus
3.4.24.11 thiorphan
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.11 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.11 brain
-
 Mus musculus
-
3.4.24.11 hippocampus neurons Mus musculus
-
3.4.24.11 neuron hippocampal Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.11 NEP
-
 Mus musculus