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Literature summary extracted from

  • Rejman, D.; Olesiak, M.; Chen, L.; Patterson, S.E.; Wilson, D.; Jayaram, H.N.; Hedstrom, L.; Pankiewicz, K.W.
    Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase (2006), J. Med. Chem., 49, 5018-5022.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.205 drug development the enzyme is a target for therapeutic drugs Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.205 C2-mycophenolic adenine dinucleotide methylenephosphophosphonate analogue of mycophenolic adenine dinucleotide Homo sapiens
1.1.1.205 C4-mycophenolic adenine dinucleotide methylenephosphophosphonate analogue of mycophenolic adenine dinucleotide Homo sapiens
1.1.1.205 mizoribine
-
 Homo sapiens
1.1.1.205 additional information inhibitor development and synthesis, overview Homo sapiens
1.1.1.205 Mycophenolic acid
-
 Homo sapiens
1.1.1.205 mycophenolic adenine dinucleotide
-
 Homo sapiens
1.1.1.205 P1-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)methylenephospho-P2-(adenosin-5'-yl)phosphonate
-
 Homo sapiens
1.1.1.205 P1-(adenosine-5'-yl)methylenephospho-P2-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)phosphonate
-
 Homo sapiens
1.1.1.205 ribavirin
-
 Homo sapiens
1.1.1.205 tiazofurin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.205 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.205 IMPDH
-
 Homo sapiens
1.1.1.205 inosine monophosphate dehydrogenase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.205 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.205 8
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.205 0.02 0.037 P1-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)methylenephospho-P2-(adenosin-5'-yl)phosphonate pH 8.0, 25°C Homo sapiens
1.1.1.205 0.06 0.087 P1-(adenosine-5'-yl)methylenephospho-P2-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)phosphonate pH 8.0, 25°C Homo sapiens
1.1.1.205 0.25 0.33 C2-mycophenolic adenine dinucleotide pH 8.0, 25°C Homo sapiens
1.1.1.205 0.38 0.52 C4-mycophenolic adenine dinucleotide pH 8.0, 25°C Homo sapiens