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Literature summary extracted from

  • Ciulli, A.; Williams, G.; Smith, A.G.; Blundell, T.L.; Abell, C.
    Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods (2006), J. Med. Chem., 49, 4992-5000.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.169 2'-phospho-ADP-ribose competitive Escherichia coli
1.1.1.169 2'-phospho-AMP competitive Escherichia coli
1.1.1.169 ADP competitive Escherichia coli
1.1.1.169 AMP competitive Escherichia coli
1.1.1.169 ATP noncompetitive Escherichia coli
1.1.1.169 additional information protein-ligand interaction determination and analysis Escherichia coli
1.1.1.169 phosphate competitive Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.169 additional information
-
 additional information kinetics and thermodynamics, overview Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.169 ketopantoate + NADPH Escherichia coli the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA pantoate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.169 Escherichia coli
-
 gene panE
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.169 (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ protein-ligand interactions, overview Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.169 ketopantoate + NADPH
-
 Escherichia coli pantoate + NADP+
-
 r
1.1.1.169 ketopantoate + NADPH the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA Escherichia coli pantoate + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.169 ketopantoate reductase
-
 Escherichia coli
1.1.1.169 KPR
-
 Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.169 7.6
-
 assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.169 additional information NAD+/NADH are poor cofactors Escherichia coli
1.1.1.169 NADP+ protein-ligand interaction determination and analysis Escherichia coli
1.1.1.169 NADPH protein-ligand interaction determination and analysis Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.169 0.2
-
 2'-phospho-ADP-ribose pH 7.6 Escherichia coli
1.1.1.169 0.24
-
 2'-phospho-AMP pH 7.6 Escherichia coli
1.1.1.169 0.61
-
 ATP pH 7.6 Escherichia coli
1.1.1.169 1.05
-
 ADP pH 7.6 Escherichia coli
1.1.1.169 6.3
-
 AMP pH 7.6 Escherichia coli
1.1.1.169 27
-
 phosphate pH 7.6 Escherichia coli