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Literature summary extracted from

  • Jeong, W.; Park, S.J.; Chang, T.S.; Lee, D.Y.; Rhee, S.G.
    Molecular mechanism of the reduction of cysteine sulfinic acid of peroxiredoxin to cysteine by mammalian sulfiredoxin (2006), J. Biol. Chem., 281, 14400-14407.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.98.2 ATP
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.8.98.2 C99A Cys99 replaced by Ala Homo sapiens
1.8.98.2 C99S Cys99 replaced by Ser Homo sapiens
1.8.98.2 D57N Asp57 replaced by Asn Homo sapiens
1.8.98.2 D79N Asp60 replaced by Asn Homo sapiens
1.8.98.2 H99N His99 replaced by Asn Homo sapiens
1.8.98.2 K60R Lys60 replaced by Arg Homo sapiens
1.8.98.2 R100M Arg100 replaced by Met Homo sapiens
1.8.98.2 R50M Arg50 replaced by Met Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.98.2 Mg2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.98.2 12000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.98.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.98.2 peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH
-
 Homo sapiens peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.98.2 Srx
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.98.2 0.003
-
 peroxiredoxin-(S-hydroxy-S-oxocysteine) at 30°C Homo sapiens