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Literature summary extracted from
- Crystal structures of the FXIa catalytic domain in complex with ecotin mutants reveal substrate-like interactions (2005), J. Biol. Chem., 280, 4704-4712.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.27 | FXIa | - |
Homo sapiens | |
| 3.4.21.27 | FXIIa | - |
Homo sapiens | |
| 3.4.21.27 | thrombin | - |
Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | medicine | anti-thrombosis therapy | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.27 | expressed in Pichia pastoris | Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 3.4.21.27 | hanging drop vapor diffusion | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.27 | anti-thrombin III | - |
Homo sapiens | |
| 3.4.21.27 | ecotin | - |
Homo sapiens | |
| 3.4.21.27 | protease hexin II | - |
Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.27 | 80000 | - |
2 * 80000, SDS-PAGE | Homo sapiens |
| 3.4.21.27 | 160000 | - |
SDS-PAGE | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.27 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.27 | immobilized Zn2-chelate chromatography and cation exchange chromatography | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.27 | L-pyroglutamyl-L-prolyl-L-arginyl-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-pyroglutamyl-L-prolyl-L-arginine + 7-amino-4-methylcoumarin | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | homodimer | 2 * 80000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.27 | activated coagulation factor XIa | - |
Homo sapiens |
| 3.4.21.27 | coagulation factor XI | - |
Homo sapiens |
| 3.4.21.27 | FXI | - |
Homo sapiens |
| 3.4.21.27 | FXIa | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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