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Literature summary extracted from

  • Seifert, J.P.; Wing, M.R.; Snyder, J.T.; Gershburg, S.; Sondek, J.; Harden, T.K.
    RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism (2004), J. Biol. Chem., 279, 47992-47997.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.11 RhoA PLC-epsilon is a direct downstream efector for RhoA. RhA-dependent activation of PLC-epsilon depends on a unique insert within the catalytic core of the phospholipase Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.11 0.006
-
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate 25°C, pH 7.4 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.11 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.11
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
-
 Rattus norvegicus 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
-
 ?
3.1.4.11 phosphatidylinositol 4-phosphate + H2O
-
 Rattus norvegicus 1D-myo-inositol 4,5-bisphosphate + diacylglycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.11 phospholipase C-epsilon
-
 Rattus norvegicus
3.1.4.11 PLC-epsilon
-
 Rattus norvegicus