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Literature summary extracted from

  • Marchetti Maria, A.; Pizarro Gresin, O.; Sagher, D.; Deamicis, C.; Brot, N.; Hejtmancik, J.F.; Weissbach, H.; Kantorow, M.
    Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells (2005), Invest. Ophthalmol. Vis. Sci., 46, 2107-2112.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.12 cytosol isozyme MsrB1 or selenoprotein R Homo sapiens 5829
-
1.8.4.12 endoplasmic reticulum isozyme MsrB3 Homo sapiens 5783
-
1.8.4.12 mitochondrion isozyme MsrB2 or CBS-1, and isozyme MsrB3 Homo sapiens 5739
-
1.8.4.12 nucleus isozyme MsrB1 or selenoprotein R Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin Homo sapiens stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.12 Homo sapiens
-
 isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.12 bone marrow isozyme MsrB1 Homo sapiens
-
1.8.4.12 cerebellum isozyme MsrB2 Homo sapiens
-
1.8.4.12 colon isozymes MsrB3 and MsrB2 Homo sapiens
-
1.8.4.12 heart isozymes MsrB3 and MsrB2 Homo sapiens
-
1.8.4.12 kidney isozyme MsrB1 and MsrB2 Homo sapiens
-
1.8.4.12 lens epithelia and fibers, isozymes MsrB1 or selenoprotein R, MsrB2 or CBS-1, and MsrB3, differential expression patterns of isozymes, overview Homo sapiens
-
1.8.4.12 additional information tissue-specific expression of MsrB isozymes, overview Homo sapiens
-
1.8.4.12 skeletal muscle isozymes MsrB1 and MsrB2 Homo sapiens
-
1.8.4.12 small intestine isozyme MsrB3 Homo sapiens
-
1.8.4.12 spleen isozyme MsrB1 Homo sapiens
-
1.8.4.12 SRA01/04 cell i.e. HLE cell, transformed human lens epithelial cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.12 L-methionine-(R)-S-oxide + thioredoxin stereospecific reduction, the isozymes of MsrB are involved in lens cell viability and oxidative stress protection Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.12 CBS-1
-
 Homo sapiens
1.8.4.12 methionine sulfoxide reductase B
-
 Homo sapiens
1.8.4.12 MsrB
-
 Homo sapiens
1.8.4.12 selenoprotein R
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.4.12 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.12 thioredoxin
-
 Homo sapiens