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Literature summary extracted from

  • Bjarnason, J.B.; Fox, J.W.
    Horrilysin (2004), Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 681-682.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.4.24.47 medicine horrilysin possesses hemorrhagic and lethal activities Crotalus horridus horridus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.47 57000
-
 SDS-PAGE Crotalus horridus horridus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.47 Crotalus horridus horridus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.47 by two step column chromatography Crotalus horridus horridus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.47 venom
-
 Crotalus horridus horridus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.47 collagen I + H2O
-
 Crotalus horridus horridus ?
-
 ?
3.4.24.47 cow hide powder + H2O hydrolysis only at 20% of the rate at which hide powder azure is hydrolyzed Crotalus horridus horridus ?
-
 ?
3.4.24.47 Denatured casein + H2O
-
 Crotalus horridus horridus ?
-
 ?
3.4.24.47 Fibrin + H2O degradation of the alpha chain Crotalus horridus horridus ?
-
 ?
3.4.24.47 Fibrinogen + H2O rapid digestion of the Aalpha chain followed by a slower degradation of the Bbeta chain Crotalus horridus horridus ?
-
 ?
3.4.24.47 glomerular basement membrane + H2O catalysis of the complete solubilization Crotalus horridus horridus ?
-
 ?
3.4.24.47 Hemoglobin + H2O
-
 Crotalus horridus horridus ?
-
 ?
3.4.24.47 hide powder azure + H2O
-
 Crotalus horridus horridus ?
-
 ?
3.4.24.47 insulin + H2O cleavage of the Val-Glu-Ala15-Leu16-Tyr-Leu bond of the B chain and Val-Cys-Ser12-Leu13-Tyr-Gly bond of the A chain Crotalus horridus horridus ?
-
 ?
3.4.24.47 Melittin + H2O cleavage at the Ile2-Gly3, Pro14-Ala15 and Ser18-Trp19 bonds Crotalus horridus horridus ?
-
 ?
3.4.24.47 additional information no cleavage of various unblocked dipeptides and the doubly blocked dipeptides Z-Ser-Leu-NH2, Z-Ala-Leu-NH2 and Z-Ile-Gly-NH2 Crotalus horridus horridus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.47 monomer
-
 Crotalus horridus horridus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.47 Hemorrhagic proteinase IV
-
 Crotalus horridus horridus
3.4.24.47 HP-IV
-
 Crotalus horridus horridus