Literature summary extracted from

Vivas, L.; Easton, A.; Kendrick, H.; Cameron, A.; Lavandera, J.L.; Barros, D.; de las Heras, F.G.; Brady, R.L.; Croft, S.L.
Plasmodium falciparum: stage specific effects of a selective inhibitor of lactate dehydrogenase (2005), Exp. Parasitol., 111, 105-114.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.1.1.27	4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid	trophozoites are the most susceptible stages to exposure to 4-hydroxy-1,2,5-oxadiazole-3-carboxylic acid	Plasmodium falciparum

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.27	Plasmodium falciparum	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.27	ring stage	-	Plasmodium falciparum	-
1.1.1.27	trophozoite	-	Plasmodium falciparum	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.27	(S)-lactate + 3-acetyl pyridine adenine dinucleotide	assay is based on reduction of 3-acetyl pyridine adenine dinucleotide that is specific for PfLDH, which allows the distinction of PfLDH from that of the host erythrocyte	Plasmodium falciparum	pyruvate + reduced 3-acetyl pyridine adenine dinucleotide	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.1.1.27	PfLDH	-	Plasmodium falciparum

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.1.1.27	3-acetylpyridine adenine dinucleotide	assay is based on reduction of 3-acetyl pyridine adenine dinucleotide that is specific for PfLDH, which allows the distinction of PfLDH from that of the host erythrocyte	Plasmodium falciparum

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Release 2023.1 (January 2023)