Literature summary extracted from

Dubois, V.; Nieder, M.; Collot, F.; Negrouk, A.; Nguyen, T.T.; Gangwar, S.; Reitz, B.; Wattiez, R.; Dasnois, L.; Trouet, A.
Thimet oligopeptidase (EC 3.4.24.15) activates CPI-0004Na, an extracellularly tumour-activated prodrug of doxorubicin (2006), Eur. J. Cancer, 42, 3049-3056.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.4.24.15	thiol	stimulation	Homo sapiens

Application

EC Number	Application	Comment	Organism
3.4.24.15	medicine	enzyme is involved in extracellular activation of CPI-0004Na prodrug	Homo sapiens

Molecular Weight [Da]

EC Number	Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
3.4.24.15	72000	-	x * 72000, SDS-PAGE	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.24.15	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.24.15	HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.24.15	CPI-0004Na + H2O	tetrapeptidic prodrug of doxorubicin	Homo sapiens	?	-	?

Subunits

EC Number	Subunits	Comment	Organism
3.4.24.15	?	x * 72000, SDS-PAGE	Homo sapiens

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Release 2023.1 (January 2023)