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Literature summary extracted from
- Multiplicity of mammalian reductases for xenobiotic carbonyl compounds (2006), Drug Metab. Pharmacokinet., 21, 1-18.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.1.1.213 | chromosomal localization is 10q15-q14, phylogenetic tree | Homo sapiens |
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.1.1.10 | - |
Mus musculus |
| 1.1.1.10 | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.1.1.213 | cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.10 | L-xylulose + NADPH + H+ | Mus musculus | uronate cycle of glucose metabolism | L-xylitol + NADP+ | - |
? |  |
| 1.1.1.10 | L-xylulose + NADPH + H+ | Homo sapiens | uronate cycle of glucose metabolism | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | Rattus norvegicus | uronate cycle of glucose metabolism | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | Sus scrofa | uronate cycle of glucose metabolism | L-xylitol + NADP+ | - |
? | |
| 1.1.1.213 | 10-oxonortriptyline + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | 3-ketosteroids + NADPH | Homo sapiens | - |
3-hydroxysteroids + NADP+ | - |
? | |
| 1.1.1.213 | 5alpha-dihydrotestosterone + NADPH | Homo sapiens | the enzyme is important in inactivation of DHT | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| 1.1.1.213 | acetohexamide + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | befunolol + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | daunorubicin + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | dolasetron + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | haloperidol + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | ketoprofen + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | ketotifen + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | loxoprofen + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | additional information | Homo sapiens | the enzyme is important in the synthesis of neuroactive 5alpha/beta-pregnan-3alpha-ol-20-ones from their precursors, the enzyme plays a role in development and progression of prostate cancer | ? | - |
? | |
| 1.1.1.213 | Naloxone + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | Naltrexone + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | oracin + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
| 1.1.1.213 | oxycodone + NADPH | Homo sapiens | a drug acting as substrate | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.10 | Homo sapiens | - |
- |
- |
| 1.1.1.10 | Mus musculus | - |
- |
- |
| 1.1.1.10 | Rattus norvegicus | - |
- |
- |
| 1.1.1.10 | Sus scrofa | - |
- |
- |
| 1.1.1.213 | Homo sapiens | P52895 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.10 | kidney | - |
Mus musculus | - |
| 1.1.1.10 | kidney | - |
Homo sapiens | - |
| 1.1.1.10 | kidney | - |
Rattus norvegicus | - |
| 1.1.1.10 | kidney | - |
Sus scrofa | - |
| 1.1.1.10 | liver | - |
Mus musculus | - |
| 1.1.1.10 | liver | - |
Homo sapiens | - |
| 1.1.1.10 | liver | - |
Rattus norvegicus | - |
| 1.1.1.10 | liver | - |
Sus scrofa | - |
| 1.1.1.213 | adipose tissue | the enzyme expression is positively correlated to adiposity in woman | Homo sapiens | - |
| 1.1.1.213 | astrocyte | high expression and activity in astrocytes of glaucomatous optic nerve head | Homo sapiens | - |
| 1.1.1.213 | additional information | wide tissue distribution | Homo sapiens | - |
| 1.1.1.213 | prostate gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.10 | L-xylulose + NADPH + H+ | - |
Mus musculus | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | - |
Homo sapiens | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | - |
Rattus norvegicus | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | - |
Sus scrofa | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | uronate cycle of glucose metabolism | Mus musculus | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | uronate cycle of glucose metabolism | Homo sapiens | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | uronate cycle of glucose metabolism | Rattus norvegicus | L-xylitol + NADP+ | - |
? | |
| 1.1.1.10 | L-xylulose + NADPH + H+ | uronate cycle of glucose metabolism | Sus scrofa | L-xylitol + NADP+ | - |
? | |
| 1.1.1.213 | 10-oxonortriptyline + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | 10-oxonortriptyline + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | 3-ketosteroids + NADPH | - |
Homo sapiens | 3-hydroxysteroids + NADP+ | - |
? | |
| 1.1.1.213 | 5alpha-dihydrotestosterone + NADPH | the enzyme is important in inactivation of DHT | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| 1.1.1.213 | 5alpha-dihydrotestosterone + NADPH | i.e. DHT | Homo sapiens | 5alpha-androstane-3alpha,17beta-diol + NADP+ | - |
? | |
| 1.1.1.213 | acetohexamide + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | acetohexamide + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | befunolol + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | befunolol + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | daunorubicin + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | daunorubicin + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | dolasetron + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | dolasetron + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | haloperidol + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | haloperidol + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | ketoprofen + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | ketoprofen + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | ketotifen + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | ketotifen + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | loxoprofen + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | loxoprofen + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | additional information | the enzyme is important in the synthesis of neuroactive 5alpha/beta-pregnan-3alpha-ol-20-ones from their precursors, the enzyme plays a role in development and progression of prostate cancer | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | Naloxone + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | Naloxone + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | Naltrexone + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | Naltrexone + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | oracin + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | oracin + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
| 1.1.1.213 | oxycodone + NADPH | - |
Homo sapiens | ? | - |
? | |
| 1.1.1.213 | oxycodone + NADPH | a drug acting as substrate | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.1.1.10 | tetramer | - |
Mus musculus |
| 1.1.1.10 | tetramer | - |
Homo sapiens |
| 1.1.1.10 | tetramer | - |
Rattus norvegicus |
| 1.1.1.10 | tetramer | - |
Sus scrofa |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.213 | 3alpha-HSD type 3 | - |
Homo sapiens |
| 1.1.1.213 | AKR1C2 | - |
Homo sapiens |
| 1.1.1.213 | bile acid-binding protein | - |
Homo sapiens |
| 1.1.1.213 | DD2 | - |
Homo sapiens |
| 1.1.1.213 | More | the enzyme is a member of the aldo-keto reductase family | Homo sapiens |
| 1.1.1.213 | type 3 3-alpha-hydroxysteroid dehydrogenase | - |
Homo sapiens |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.10 | additional information | - |
rapidly dissociates into the inactive dimeric form at low temperature | Mus musculus |
| 1.1.1.10 | additional information | - |
rapidly dissociates into the inactive dimeric form at low temperature | Rattus norvegicus |
| 1.1.1.10 | additional information | - |
rapidly dissociates into the inactive dimeric form at low temperature | Sus scrofa |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.10 | NADPH | - |
Mus musculus | |
| 1.1.1.10 | NADPH | - |
Homo sapiens | |
| 1.1.1.10 | NADPH | - |
Rattus norvegicus | |
| 1.1.1.10 | NADPH | - |
Sus scrofa | |
| 1.1.1.213 | NADPH | - |
Homo sapiens | |
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