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Literature summary extracted from

  • Basu, R.; Edgerton, D.S.; Singh, R.J.; Cherrington, A.; Rizza, R.A.
    Splanchnic cortisol production in dogs occurs primarily in the liver: evidence for substantial hepatic specific 11beta hydroxysteroid dehydrogenase type 1 activity (2006), Diabetes, 55, 3013-3019.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 cortisol + NAD+ Canis lupus familiaris pathway overview cortisone + NADH
-
 ir
1.1.1.146 cortisone + NADPH + H+ Canis lupus familiaris pathway overview cortisol + NADP+
-
 ir
1.1.1.146 additional information Canis lupus familiaris high local cortisol concentrations generated via the 11beta-HSD1 pathway within the liver likely contribute to the regulation of hepatic glucose, fat, and protein metabolism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Canis lupus familiaris
-
-
-
1.1.1.146 Canis lupus familiaris
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 adipocyte
-
 Canis lupus familiaris
-
1.1.1.B40 hepatocyte primary Canis lupus familiaris
-
1.1.1.B40 liver hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview Canis lupus familiaris
-
1.1.1.B40 viscus splanchnic activity Canis lupus familiaris
-
1.1.1.146 adipocyte
-
 Canis lupus familiaris
-
1.1.1.146 hepatocyte primary Canis lupus familiaris
-
1.1.1.146 liver hepatic artery, portal vein, and hepatic vein, local cortisol concentrations, overview Canis lupus familiaris
-
1.1.1.146 viscus splanchnic activity Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.B40 additional information
-
 splanchnic, visceral, and hepatic net cortisol balance, cortisol uptake, and cortisol production, overview Canis lupus familiaris
1.1.1.146 additional information
-
 splanchnic, visceral, and hepatic net cortisol balance, cortisol uptake, and cortisol production, overview Canis lupus familiaris

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 cortisol + NAD+ pathway overview Canis lupus familiaris cortisone + NADH
-
 ir
1.1.1.146 cortisone + NADPH + H+ pathway overview Canis lupus familiaris cortisol + NADP+
-
 ir
1.1.1.146 additional information high local cortisol concentrations generated via the 11beta-HSD1 pathway within the liver likely contribute to the regulation of hepatic glucose, fat, and protein metabolism Canis lupus familiaris ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta hydroxysteroid dehydrogenase type 2
-
 Canis lupus familiaris
1.1.1.B40 isozyme 11beta-HSD2
-
 Canis lupus familiaris
1.1.1.146 11beta hydroxysteroid dehydrogenase type 1
-
 Canis lupus familiaris
1.1.1.146 isozyme 11beta-HSD1
-
 Canis lupus familiaris

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Canis lupus familiaris
1.1.1.146 NADPH
-
 Canis lupus familiaris