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Literature summary extracted from

  • Mai, K.; Kullmann, V.; Bobbert, T.; Maser-Gluth, C.; Moehlig, M.; Baehr, V.; Pfeiffer, A.F.; Spranger, J.; Diederich, S.
    In vivo activity of 11beta-hydroxysteroid dehydrogenase type 1 and free fatty acid-induced insulin resistance (2005), Clin. Endocrinol. (Oxf.), 63, 442-449.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ Homo sapiens isozyme 11beta-HSD1, the enzyme seems not to be involved in free fatty acid-induced insulin resistance, overview cortisol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
 male
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.146 additional information
-
 in vivo isozyme 11beta-HSD1 activity during heparin/lipid or glucose infusion, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1 Homo sapiens cortisol + NADP+
-
 ?
1.1.1.146 cortisone + NADPH + H+ isozyme 11beta-HSD1, the enzyme seems not to be involved in free fatty acid-induced insulin resistance, overview Homo sapiens cortisol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADPH
-
 Homo sapiens