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Literature summary extracted from

  • Wolfs, J.L.; Comfurius, P.; Rasmussen, J.T.; Keuren, J.F.; Lindhout, T.; Zwaal, R.F.; Bevers, E.M.
    Activated scramblase and inhibited aminophospholipid translocase cause phosphatidylserine exposure in a distinct platelet fraction (2005), Cell. Mol. Life Sci., 62, 1514-1525.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.1 additional information Ca2+-stimulated phosphatidylserine exposure at the surface activates the enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.1 EDTA
-
 Homo sapiens
7.6.2.1 additional information no inhibition by NEM Homo sapiens
7.6.2.1 NEM
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.1 plasma membrane preparation of microparticles for in vitro assay Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
7.6.2.1 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.1 ATP + H2O + phosphatidylserine/out Homo sapiens transport from the external leaflet of the membrane to the inner leaflet, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the scramblase activity, overview ADP + phosphate + phosphatidylserine/in
-
 ?
7.6.2.1 phosphatidylserine/out Homo sapiens bidirectional transport, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the aminophospholipid translocase activity, overview phosphatidylserine/in
-
 r

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.1 blood platelet the enzyme is only active in the platelet fraction which does expose phosphatidylserine, and is inactive int he platelet fraction not exposing phosphatidylserine, overview Homo sapiens
-
7.6.2.1 blood platelet the enzyme occurs only in the platelet fraction which does not expose phosphatidylserine Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.1 ATP + H2O + phosphatidylserine/out transport from the external leaflet of the membrane to the inner leaflet, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the scramblase activity, overview Homo sapiens ADP + phosphate + phosphatidylserine/in
-
 ?
7.6.2.1 ATP + H2O + phosphatidylserine/out 7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, transport from the external leaflet of the membrane to the inner leaflet Homo sapiens ADP + phosphate + phosphatidylserine/in
-
 ?
7.6.2.1 additional information the enzyme does not require energy supply by ATP hydrolysis Homo sapiens ?
-
 ?
7.6.2.1 phosphatidylserine/out bidirectional transport, the enzyme controls the level of phosphatidylserine exposed to the platelet surface antagonizing to the aminophospholipid translocase activity, overview Homo sapiens phosphatidylserine/in
-
 r
7.6.2.1 phosphatidylserine/out 7-nitro-2-1,3-benzoxadiazol-4-yl-fluorescent-labeled substrate, bidirectional transport Homo sapiens phosphatidylserine/in
-
 r

Synonyms

EC Number Synonyms Comment Organism
7.6.2.1 aminophospholipid scramblase
-
 Homo sapiens
7.6.2.1 aminophospholipid translocase
-
 Homo sapiens
7.6.2.1 scramblase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.6.2.1 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6.2.1 7.5
-
 assay at Homo sapiens