Literature summary extracted from

Babbitt, S.E.; Kiss, A.; Deffenbaugh, A.E.; Chang, Y.H.; Bailly, E.; Erdjument-Bromage, H.; Tempst, P.; Buranda, T.; Sklar, L.A.; Baumler, J.; Gogol, E.; Skowyra, D.
ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle (2005), Cell, 121, 553-565.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5.6.1.5	ATP + H2O + polypeptide	Saccharomyces cerevisiae	ATP hydrolysis is required for degradation of polyubiquitinated proteins by the 26S proteasome. ATP hydrolysis triggers rapid dissociation of the 19S regulatory particles from immunopurified 26S complexes in a manner coincident with release of the bulk of proteasome-interacting proteins. A controlled dissociation of the 19S regulatory particles from the 26S proteasome is part of the mechanism of protein degradation	ADP + phosphate + unfolded polypeptide	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.6.1.5	Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.6.1.5	ATP + H2O + polypeptide	ATP hydrolysis is required for degradation of polyubiquitinated proteins by the 26S proteasome. ATP hydrolysis triggers rapid dissociation of the 19S regulatory particles from immunopurified 26S complexes in a manner coincident with release of the bulk of proteasome-interacting proteins. A controlled dissociation of the 19S regulatory particles from the 26S proteasome is part of the mechanism of protein degradation	Saccharomyces cerevisiae	ADP + phosphate + unfolded polypeptide	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)