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Literature summary extracted from
- Activity of 11beta-hydroxysteroid dehydrogenase in tissues of hypertensive NISAG rats (2006), Bull. Exp. Biol. Med., 141, 30-32.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | Rattus norvegicus | - |
isozymes 11beta-HSD1 and 11beta-HSD2, male WAG rats, male hypertensive NISAG rats, i.e. rat strain with hereditary stress-induced arterial hypertension | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.1.1.146 | kidney | renal cortex, 1.5fold higher enzyme activity in hypertensive NISAG rats, i.e. rat strain with hereditary stress-induced arterial hypertension, compared to WAG rats | Rattus norvegicus | - |
| 1.1.1.146 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.146 | additional information | - |
plasma corticosterone concentration of WAG and NISAG rats, overview | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.1.1.146 | corticosterone + NADP+ | - |
Rattus norvegicus | ? | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.1.1.146 | 11beta-HSD1 | - |
Rattus norvegicus |
| 1.1.1.146 | 11beta-HSD2 | - |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.1.1.146 | 8.5 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.1.1.146 | NADP+ | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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