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Literature summary extracted from

  • Johner, A.; Kunz, S.; Linder, M.; Shakur, Y.; Seebeck, T.
    Cyclic nucleotide specific phosphodiesterases of Leishmania major (2006), BMC Microbiol., 6, 25.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.53 expression in Escherichia coli Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one
-
 Leishmania major
3.1.4.53 dipyridamole
-
 Leishmania major
3.1.4.53 etazolate
-
 Leishmania major
3.1.4.53 Milrinone
-
 Leishmania major
3.1.4.53 papaverine
-
 Leishmania major
3.1.4.53 rolipram
-
 Leishmania major

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.53 0.00099
-
 3',5'-cAMP
-
 Leishmania major
3.1.4.53 0.00698
-
 3',5'-cAMP
-
 Leishmania major

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Leishmania major Q6S996
-
-
3.1.4.53 Leishmania major Q6S997
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O LmjPDEB1 is completely cAMP-specific Leishmania major 5'-AMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O LmjPDEB2 is completely cAMP-specific Leishmania major 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 class I phosphodiesterase PDEB1
-
 Leishmania major
3.1.4.53 class I phosphodiesterase PDEB2
-
 Leishmania major
3.1.4.53 LmjPDEB1
-
 Leishmania major
3.1.4.53 LmjPDEB2
-
 Leishmania major